Here, we will review the characteristics of the mdr1a -/- model of spontaneous colitis that we believe make this model an important part of the IBD researcher's toolbox. We will also share …

1998年11月15日 · The intestinal inflammation seen in mdr1a −/− mice has a pathology similar to that of human inflammatory bowel disease (IBD) and is defined by dysregulated epithelial cell …

In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the …

Here, we will review the characteristics of the mdr1a −/− model of spontaneous colitis that we believe make this model an important part of the IBD researcher's toolbox. We will also share …

2025年2月6日 · The Mdr1a knockout (KO) mouse model is increasingly used in IBD research due to its ability to mimic human colitis through microbiome-driven inflammation and a …

2004年1月2日 · Panwala等发现将mdr1a基因敲除（mdr1a-/-）的小鼠置于无特异性病原体（SPF）环境下，可诱导出与人类溃疡性结肠炎（UC）类似的模型[Panwala CM , Jones JC , …

2013年10月1日 · This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multidrug resistance targeted mutation (Mdr1a −/−) …

Mdr1a knockout mice have a barrier defect that leads to spontaneous colitis in response to the enteric microbiota. Il10 knockout mice develop spontaneous colitis and

1998年11月15日 · The murine multiple drug resistance (mdr) gene, mdr1a, encodes a 170-kDa transmembrane protein that is expressed in many tissues including intestinal epithelial cells, a …

In this review article, we briefly introduce 74 kinds of genetically engineered mouse models that spontaneously develop intestinal inflammation. Keywords: epithelial barrier, ER stress, …