MAP3K2 - Wikipedia
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene. [5] [6] [7]
经典信号通路总结——MAPK信号通路 - 知乎 - 知乎专栏
mapk（丝裂原活化蛋白激酶）通路有三级的信号传递过程：mapk，mapk激酶（mek或mkk）以及mapk激酶的激酶（mekk或mkkk）。这三种激酶能依次激活，共同调节着细胞的生长、分化、 …
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I - Nature
2020年11月11日 · Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation and that MEKK2 inhibitors, including ponatinib, ameliorate skeletal defects in a …
MEKK2在固有免疫抗细菌感染中的调控机制 - 百度百科
利用mekk2 ko小鼠，我们发现：1、细菌感染可以激活mekk2。2、ko小鼠对内毒素引起的感染性休克有缺陷。3、李斯特菌感染后，ko 巨噬细胞生成细胞因子较少。因此，mekk2可能在抗菌感 …
MEKK2 inhibits activation of MAP kinases in Arabidopsis
In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense …
MEKK2 and MEKK3 suppress Hedgehog pathway-dependent
2018年4月17日 · Here we show that MEKK2 (MAP3K2) and MEKK3 (MAP3K3) inhibit GLI1 transcriptional activity and oncogenic function through phosphorylation on multiple Ser/Thr …
Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2 …
2023年5月19日 · Best3-MEKK2/3 signaling represents a novel therapeutic target for AD. These findings unveil a critical role of Best3 in regulating smooth muscle cell phenotypic switch and …
MEKK2和MEKK3在炎症与血管发育中的功能及机制研究 - 道客巴巴
2017年12月19日 · 内容提示： 上海交通大学医学院 2013 级博士研究生学位论文 mekk2 和 和 mekk3 在炎症 与 血管 发育 中的 功能及机制研究 作者姓名：邓汉强 学 号：0137109043 指导 …
MEKK2 inhibits activation of MAP kinases in Arabidopsis
2020年4月8日 · Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by …
PNAS Plus: MEKK2 mediates an alternative β-catenin pathway that ...
2016年3月1日 · The ability of MEKK2 to increase β-catenin levels resulted from posttranslational regulation of β-catenin stability, because β-catenin transcript levels were not altered by the …