Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. [6] Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical cancers.

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor in endocrine organs, it is required for leukemic transformation in mouse ...

Multiple endocrine neoplasia type 1 (MEN1) is a rare genetic disorder that mainly affects the endocrine glands. Located in different parts of the body, these glands control the production of hormones that direct many body processes, including growth, digestion, and sexual function. MEN1 can affect the parathyroids, pancreas, and pituitary glands.

2024年12月25日 · This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones.

2025年1月11日 · Menin抑制剂已成为一种有前景的治疗方法，可靶向 AML 的关键遗传驱动因素，如 KMT2A 重排和 NPM1 突变。 《Blood》近日发表综述，阐述了menin 抑制剂的临床价值，突出其作用机制、疗效、安全性和转化 AML 治疗的潜力。 表观遗传. 基因转录改变导致各种生物学过程紊乱，是癌症的标志，也是髓系恶性肿瘤如急性髓系白血病 (AML) 多步骤发展的基础。 异常基因调控可能是染色体异常或基因突变的结果，但也可能是表观遗传学改变的结果（即对 DNA …

2025年2月8日 · This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation.

DS-1594是一种有效的选择性小分子menin抑制剂，被设计用于靶向和破坏menin和MLL的蛋白-蛋白相互作用，以抑制白血病细胞的生长和增殖。在临床前研究中，DS-1594显示出对AML和ALL细胞的选择性生长抑制，并在AML模型中表现出强大和持久的抗肿瘤活性，具有可接受的 ...

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary tumor syndrome with a high degree of penetrance, that is caused by inactivating mutations of the tumor suppressor gene MEN1, and is characterized by a predisposition to a multitude of endocrine and nonendocrine tumors (1).

多发性内分泌腺瘤病1型（MEN-1）是常染色体显性综合征，特点为增生，或是腺瘤、胰岛细胞瘤 (也称为胰腺神经内分泌肿瘤)，和/或垂体肿瘤。 十二指肠促胃液瘤、空肠的良性肿瘤、肾上腺的良性肿瘤以及脂肪瘤也可能存在。 甲状旁腺功能亢进症和无症状高钙血症常发生。 为家庭成员提供基因筛查。 诊断依靠激素测定及影像学检查。 如果肿瘤引起症状或根据大小标准怀疑为恶性肿瘤，则通过手术切除。 (参见多发性内分泌肿瘤概述。 MEN-1可能是由于编码转录因子menin …

MEN1（multiple endocrine neoplasia 1，多发性内分泌腺瘤致病因子1）是于1998年由Olufemi 等人从多发性内分泌腺瘤患者中克隆成功的，位于11q13染色体上。 MEN 1基因含10个外显子，编码由610个氨基酸残基组成的核蛋白menin。