Learn how spatially resolved transcriptomics with MERFISH technology enables the deep profiling of the expression of RNAs in single cells in their native context revealing cell type, state, …

2025年2月21日 · MERFISH is an imaging method capable of simultaneously measuring the copy number and spatial distribution of hundreds to thousands of RNA species in single cells. This …

2015年4月24日 · Numerous RNA species can be identified, counted, and localized in a single cell by using MERFISH, a single-molecule imaging approach that uses combinatorial labeling and …

Here we report MERFISH, a highly multiplexed smFISH imaging method that substantially increases the number of RNA species that can be simultaneously imaged in single cells by …

2015年4月24日 · Here, we report multiplexed error-robust fluorescence in situ hybridization (MERFISH), a single-molecule imaging approach that allows the copy numbers and spatial …

2023年12月13日 · By imaging approximately 10 million cells with MERFISH and integrating the MERFISH data with a whole-brain scRNA-seq dataset, we determined the spatial organization …

MERFISH combines the power of single-cell transcriptomics with spatial biology by directly visualizing and counting up to a billion RNA transcripts from 100’s to 10,000 genes across …

2019年5月22日 · Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows simultaneous imaging of numerous RNA species in their native cellular environment and …

2018年3月19日 · As an image-based single-cell transcriptomics approach, multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows hundreds to thousands of RNA …

2022年10月21日 · Using this epigenomic MERFISH method, we demonstrated the ability to profile epigenetic modifications on chromatin, including modifications marking active promoters, …