2011年12月13日 · Eribulin Mesylate (E7389): Review of Efficacy and Tolerability in Breast, Pancreatic, Head and Neck, and Non–Small Cell Lung Cancer. Sarah L. Scarpace PharmD, …

Gabexate mesylate (GM-Foy ®) is a synthetic inhibitor of trypsin-like serine proteases [71] with an antiproteinase activity on plasma proteases, including thrombin, plasmin, trypsin, kallikrein, C1 …

Nafamostat mesylate is a potent serine protease inhibitor that has been widely used in Japan for the treatment of acute pancreatitis, disseminated intravascular coagulation, and also as an …

The mesylate salt of 44 was first dosed in Mar. 2013 to patients with EGFRm + advanced NSCLC, who had disease progression following treatment with an EGFR TKI (including 1 or 2). Based …

2014年1月1日 · Imatinib mesylate was the first molecularly targeted protein kinase inhibitor to receive FDA approval. It targets the BCR–ABL tyrosine kinase, which underlies CML. A single …

The optimal temperature for the mesylation was found to be near ambient, with gentle heating affording essentially the same impurity profile (entries 3 and 4). Interestingly, running the …

2006年6月1日 · Under these reaction conditions, there seems to be negligible potential for alkyl mesylate formation, since this would involve nucleophilic displacement of hydroxide ion (an …

2021年12月1日 · Mesylate salt is administered parenterally, while phentolamine HCl is administered orally. Thus, phentolamine mesylate is considered more useful and less toxic …

2000年4月5日 · Seven salts of LY333531 (hydrochloride, sulfate, mesylate, succinate, tartrate, acetate and phosphate) were evaluated during the early phase of development. Physical …

2023年7月1日 · For dabigatran etexilate mesylate, milling is an optional process step in situations where the specified particle size distribution is not met directly by crystallization. Therefore, …