Methionine aminopeptidase 2, a member of the dimetallohydrolase family, is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins. [7][8][9] MetAP2 is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. [7] .

2024年12月25日 · METAP2 (Methionyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with METAP2 include Microsporidiosis and Liver Rhabdomyosarcoma . Among its related pathways are Visual phototransduction and Arg/N-end rule pathway (eukaryotic) .

编码的蛋白质通过保护真核起始因子 2 的 α 亚基免受抑制性磷酸化以及通过从新生蛋白质中去除氨基末端甲硫氨酸残基来发挥作用。 这种基因表达的增加与各种形式的癌症有关，抗癌药物夫马洁林和 ovalicin 通过不可逆地与其活性位点结合来抑制这种蛋白质。 该基因的抑制剂也已被证明可有效治疗肥胖症。 该基因的假基因位于 2 号染色体上。 已发现该基因的几种编码不同亚型的转录变体。 [RefSeq 提供，2015 年 11 月] The protein encoded by this gene is a member of the …

2021年10月1日 · For over three decades, methionine aminopeptidase 2 (MetAP2) has been a tentative drug target for the treatment of cancer, obesity, and autoimmune diseases. Currently, no MetAP2 inhibitors (MetAP2i) have reached the clinic yet, despite considerable investment by major pharmaceutical companies.

2024年12月10日 · This review provides a comprehensive analysis of MetAP2, including its structural characteristics, catalytic mechanism, and functional roles in the pathophysiology of T2DM and obesity. The unique architecture of MetAP2’s active site and its interactions with substrates are examined to elucidate its enzymatic function.

2025年2月9日 · Results show that methionine aminopeptidase-2 (MetAP2) regulates angiogenesis in glioblastoma and identify MetAP2-specific substrates that may serve as candidates for clinical assay development. Suggest MetAP2 as important regulator of proliferation/apoptosis in non-small cell lung cancers.

2002年7月1日 · Methionine aminopeptidase type 2 (MetAP2) is a bifunctional protein that plays critical roles in the regulation of protein synthesis and post-translational processing by...

2024年11月27日 · Results show that methionine aminopeptidase-2 (MetAP2) regulates angiogenesis in glioblastoma and identify MetAP2-specific substrates that may serve as candidates for clinical assay development. Title: Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2.

Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and telencephalon.

利用先前报道的metap2和parp1的小分子配体，研究人员开发了tram，结合这两种蛋白中的一种和fkbp12f36v。 然后，他们利用基因编辑技术构建了表达靶蛋白-FKBP12F36V融合体的细胞，并证明，TRAM可与穿梭蛋白结合以改变被标记的靶蛋白的定位。