2022年4月29日 · Utilizing several genetic mouse models, high resolution imaging, and transcriptomic profiling, we show that Mfn1 and 2 act in tandem to preserve β-cell …

2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells. In contrast, MFN1 loss or mitochondrial shape …

2023年1月12日 · Here we report a small molecule agonist, S89, that specifically promotes mitochondrial fusion by targeting endogenous MFN1. S89 interacts directly with a loop region …

We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1) in POMC neurons couple nutrient sensing with systemic glucose metabolism. Mice lacking MFN1 in POMC neurons …

MFN1 KO disturbs the P13K-AKT pathway and interaction with other somatic cells, thus blocking folliculogenesis and oocyte growth (Carvalho et al., 2020). A study on the role of MFN1 in …

2014年11月11日 · In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6. This interaction leads to MFN1 deacetylation and …

2025年3月4日 · Mitochondrial fusion occurs through the mediation of.by MFN1, MFN2, and optic atrophy protein 1 (OPA1), and mitochondrial fission is mediated by Drp1 ... and Fgf13 …

Mfn1 and 2 single KO cells (mouse embryonic fibroblasts) were transfected with wild type DLP1 and immunostained for DLP1 and cytochrome c for mitochondrial morphology. Mitochondria …

Mechanism and regulation of mitochondrial dynamics. Mitochondrial fusion (upper left panel) is mediated by large dynamin-related GTPase proteins Mfn1, Mfn2, and OPA1. Mitochondrial …

2022年7月7日 · While both MFN1 and MFN2 deficient cells display a clearly fragmented mitochondrial network, MFN1 knockout cells display severe mitochondrial fragmentation with …