
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a
2022年4月29日 · Utilizing several genetic mouse models, high resolution imaging, and transcriptomic profiling, we show that Mfn1 and 2 act in tandem to preserve β-cell …
Mitofusin 2 displays fusion-independent roles in proteostasis ...
2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells. In contrast, MFN1 loss or mitochondrial shape …
Small molecule agonist of mitochondrial fusion repairs ... - Nature
2023年1月12日 · Here we report a small molecule agonist, S89, that specifically promotes mitochondrial fusion by targeting endogenous MFN1. S89 interacts directly with a loop region …
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for …
We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1) in POMC neurons couple nutrient sensing with systemic glucose metabolism. Mice lacking MFN1 in POMC neurons …
A detailed review of pharmacology of MFN1 (mitofusion-1) …
MFN1 KO disturbs the P13K-AKT pathway and interaction with other somatic cells, thus blocking folliculogenesis and oocyte growth (Carvalho et al., 2020). A study on the role of MFN1 in …
MFN1 deacetylation activates adaptive mitochondrial fusion and …
2014年11月11日 · In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6. This interaction leads to MFN1 deacetylation and …
Important regulatory role of mitophagy in diabetic microvascular ...
2025年3月4日 · Mitochondrial fusion occurs through the mediation of.by MFN1, MFN2, and optic atrophy protein 1 (OPA1), and mitochondrial fission is mediated by Drp1 ... and Fgf13 …
Mfn1 and 2 single KO cells (mouse embryonic fibroblasts) were...
Mfn1 and 2 single KO cells (mouse embryonic fibroblasts) were transfected with wild type DLP1 and immunostained for DLP1 and cytochrome c for mitochondrial morphology. Mitochondria …
Mitochondrial Dynamics: Molecular Mechanisms, Related Primary ...
Mechanism and regulation of mitochondrial dynamics. Mitochondrial fusion (upper left panel) is mediated by large dynamin-related GTPase proteins Mfn1, Mfn2, and OPA1. Mitochondrial …
Modulating mitofusins to control mitochondrial function and
2022年7月7日 · While both MFN1 and MFN2 deficient cells display a clearly fragmented mitochondrial network, MFN1 knockout cells display severe mitochondrial fragmentation with …