2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells. In contrast, MFN1 loss or mitochondrial shape alterations do not alter protein...

2018年2月28日 · MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function. MFN2 modulates...

2022年4月29日 · Utilizing several genetic mouse models, high resolution imaging, and transcriptomic profiling, we show that Mfn1 and 2 act in tandem to preserve β-cell mitochondrial health and, consequently,...

2024年6月21日 · By combining our observations in Mfn2 KO MEFs and KD sensory neurons, we propose that axonal degeneration caused by MFN2 loss of function mutations may not depend on impaired mitochondrial fusion or functional mitochondria/ER tethering, but rather on loss of MFN2-dependent regulation of mitochondrial transport by interfering with ATAT1 ...

2021年1月21日 · MFN2 expression was significantly correlated with cell adhesion molecules and epithelial to mesenchymal transition (EMT) in a gene-set enrichment assay. MFN2 knock-out (KO) in Cal62 and HTH83 cells using CRISPR/Cas9 or siRNA significantly promoted cell migration and invasion in vitro.

2021年7月7日 · To better understand the role of Mfn2 in MERCs in neurons in vivo, we characterized MERCs in the pyramidal neurons of hippocampi in Mfn2 conditional knockout (cKO) mice and in Mfn2 overexpressing mice, and further explored the functional consequence of MERC changes in SH-SY5Y cells with manipulated Mfn2 expression.

线粒体融合蛋白2 （Mitofusion2, Mfn2）是在MAMs结构里起到物理连接作用的蛋白之一， 研究表明线粒体外膜和内质网膜上的两个Mitofusin2分子可以形成二聚体从而将两者距离拉近 【8】。 2019年5月2日，来自巴塞罗那科学技术研究院的Antonio Zorzano与MariaIsabel Hernandez-Alvarez合作在 Cell 上发表文章 Deficient EndoplasmicReticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease，发现 Mfn2可以和PS直接互作，并介导PS在线粒体和内质网之 …

MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function. MFN2 modulates ER−mitochondria tethering. Several mutations in the Mfn2 gene, particularly in the GTPase domain, are associated to CMT2A.

2021年11月23日 · Using platelet/megakaryocyte specific Mfn2-/-(Mfn2 KO) mice, we show that Mfn2 impacts platelet numbers, activation and function by regulating mitochondrial energetics. Platelets without Mfn2 had reduced mitochondrial membrane potential and significantly reduced platelet lifespan (P<0.01) that was attributed to an increased rate of ...

2021年11月1日 · Mitofusin 2 (Mfn2), an outer mitochondrial membrane fusion protein specializes in mediating mitochondrial homeostasis. Early studies defined the biological significance of Mfn2, while latter studies highlighted its role in substrate metabolism. However, determining Mfn2 potential to contribute to energy homeostasis needs study.