The effectiveness of C5 inhibition in human trials, which will be discussed later in this review, offers further compelling evidence that complement is a critical mediator of MG. The relative …

Preclinical studies have confirmed the efficacy of complement inhibition in ameliorating MG symptoms. Eculizumab, an antibody directed towards C5, has recently been approved for the …

2023年的8月30日，阿斯利康旗下研发的第三代C5抑制剂Gefurulimab在中国开展了 III期临床试验ALXN1720-MG-301（登记号：CTR20232711），目标群体为全身型重症肌无力患者。

2023年5月30日 · New biologics are rapidly opening up target-specific therapeutic opportunities for myasthenia gravis (MG) — an autoimmune disease caused by antibodies against …

2024年12月25日 · Eculizumab, an inhibitor to target human C5 component of the complement cascade, is considered a treatment option for refractory generalized MG (gMG). Objectives: To …

2017年12月21日 · Current MG therapies do not target complement directly. Eculizumab is a humanized monoclonal antibody that inhibits cleavage of complement protein C5, preventing …

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Crovalimab是新一代抗补体C5抗体，由Chugai公司使用回收抗体（Smart-Ig）工程化改造技术研发。其通过结合C5 β链上的表位（与eculizumab和ravulizumab结合表位不同），阻断C5裂解 …

Thus far, only eculizumab, an antibody against C5, has reached the clinic. We review the present status of monoclonal antibody-based treatments for MG that have entered human testing and …

Ravulizumab 是一种人源化单克隆抗体，以高亲和力特异性结合人末端补体蛋白 C5，防止神经肌肉传递中断，可能是通 过抑制膜攻击复合物介导的神经肌肉接头破坏。 Ravulizumab 的设计 …