Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets .

Megakaryocyte growth and development factor (MGDF) is a ligand for the Mpl receptor related to thrombopoietin (TPO). MGDF stimulates megakaryocytopoiesis and thrombopoiesis, and is highly selective to cells bearing the Mpl receptor. Studies done in rodents, nonhuman primates, and humans have confirm …

促血小板生成素 （英語： Thrombopoietin，縮寫爲「THPO」），亦作「巨核細胞生長衍生因子」（MGDF），是一種人體內由促血小板生成素（THPO） 基因 編碼的類 激素。 其化學本質爲 糖蛋白，主要由腎臟和肝臟分泌，能刺激可以產生大量血小板的 巨核細胞 的形成和分化，進而促進血小板的生成 [1]。 這種蛋白質是 MLP/C_MPL 的 配體。 MLP/C_MPL 是一種骨髓增生性白血病病毒癌基因的表達產物 [2]。 編碼促血小板生成素的基因位於人 3號染色體 的長臂上（q26.3-27） …

1995年10月1日 · Megakaryocyte growth and development factor (MGDF) is a novel cytokine which promotes the development of immature megakaryocytes into platelets. We tested the hypothesis that MGDF would alter the sensitivity of platelets to aggregating agents as assessed by in-vitro platelet aggregometry.

促血小板生成素 (TPO)也称为巨核细胞生长发育因子 (MGDF)，是由肝脏实质细胞、肝窦内皮细胞和肾小管细胞产生的糖蛋白激素。 横纹肌和骨髓基质细胞也有少量表达。 它可刺激巨核细胞分泌和分化形成大量血小板。 正常和病理状态下均可测到循环的TPO，包括 特发性血小板减少性紫癜 (ITP)、特发性血小板增多症 (ET)、肝硬化、无巨核细胞性血小板减少症 (AMT)和贫血 (AA)。 巨核细胞数量调控可TPO水平，而血小板可调控血浆TPO水平，血小板数量和血液TPO水平之间看 …

MGDF stimulates megakaryocytopoiesis in patients with AML in first remission, restoring the Meg-CFC compartment to normal values, a result with potential clinical implications for

The aim of the study is to define the ability of Flt3 ligand, MGDF, Epo and G-CSF to modulate the expan-sion of different hematopoietic compartments in associ-ation with a basic cocktail of SCF +...

Megakaryocyte growth and development factor (MGDF), or thrombopoietin, has received considerable attention as a therapeutic agent for treating thrombocytopenia or for its use in the ex vivo culture of hematopoietic stem cells. MGDF is known to support the growth of a broad spectrum of hematopoietic …

Megakaryocyte growth and development factor (MGDF), an Mpl ligand, recently entered clinical trials worldwide and has been demonstrated to have potent biological activity. MGDF administration causes a dose-dependent increase in platelet count but no effect on white cell count or hematocrit.

1997年10月1日 · Megakaryocyte growth and development factor (MGDF), a Mpl ligand, recently entered clinical trials worldwide and has been demonstrated to have potent biological activity. MGDF administration causes a dose-dependent increase in platelet count but no effect on white cell count or hematocrit.