2025年2月9日 · Primary fibroblast cultures and tissues from Rb1 (deltaG) mice exhibit derepression of direct pRB-E2F transcriptional targets and yet maintain the ability to control proliferation. despite an expanded mucosal surface area, Rb-knockout in the intestinal epithelium mice demonstrate impaired lipid absorption without compensatory alterations in ...

2004年2月29日 · To complement and extend the explant culture studies in vivo, we inactivated the gene Rb1 in the retina by using a new tissue-specific Cre transgenic line (Chx10-cre) crossed to Rb1lox mice....

Here we report that inactivation of pRb target Skp2 (refs. 7,8) completely prevents spontaneous tumorigenesis in Rb1(+/-) mice. Targeted Rb1 deletion in melanotrophs ablates the entire pituitary intermediate lobe when Skp2 is inactivated.

2006年8月28日 · Heterozygous Rb1 null mice develop normally, but spontaneously develop pituitary tumors of the intermediate and anterior lobes as well as medullary thryroid carcinomas with...

2017年1月6日 · Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen therapy.

2016年10月14日 · Here, we show by CRISPR/Cas9 techniques that similar to the mouse, neither rb1 nor rbl1 single mosaic mutant Xenopus tropicalis develop tumors, whereas rb1/rbl1 double mosaic mutant tadpoles...

2015年2月23日 · We have generated an inducible RB1 DN transgenic mouse model that combines the straightforward strategy of the Dox-dependent transcriptional system to the fusion of the lysosomal protease CB with Rb1 to generate a …

2015年8月14日 · To study the induction of genomic imprinting of mouse Rb1 by introduction of a proven human gDMR, we generated Rb1_PPP1R26P1 knock-in mice to pass the human PPP1R26P1 pseudogene through the mouse germ line. Our results show that human CpG85 does not function as gDMR in the mouse, but acquires tissue-specific DNA …

View mouse Rb1 Chr14:73430298-73563446 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted deletion in mice (Jacks, et al., Clarke, et al., Lee, et al., 1992). Children with a …