In this review, we introduce the basic principles of microbubbles as ultrasound contrast agents and provide a brief description of commercialized products, as well as research on and applications of microbubbles and ultrasound for the treatment of various diseases.

Microbubbles provide a unique range of responses to ultrasound, which makes them useful for contrast ultrasound imaging, identifying molecular expression and targeting drugs to specific tissue sites.

2024年6月10日 · Microbubbles are intravenous contrast agents used in contrast-enhanced ultrasound. Microbubble contrast agent is different to the agitated saline contrast agent often used in echocardiographic studies. Microbubbles consist of a gas surrounded by a lipid, lipopolymer, or polymer shell. They range from 2-10 µm.

2004年8月1日 · Recent studies demonstrated the potential of microbubbles and ultrasound in thrombolysis. In this article, we will review the recent advances of microbubbles as a vehicle for delivery of drugs and genes, and discuss possible therapeutic applications in thrombolysis.

In just 1 milliliter of suspension of a commonly used ultrasound contrast agent there are about 500 to 600 million microbubbles. These can be administered into the body via different routes and enhance the ultrasound reflection of the sound waves, resulting in an ultrasound image with high echogenicity, ie, contrast.

Microbubbles provide inherently high contrast for ultrasound imaging – yet can also act as a potent mediator for ultrasound therapeutics. The physical interaction between microbubbles and acoustic energy allows modulation of local permeability of both …

2023年7月19日 · Microbubbles were originally developed in the 1990s to enhance ultrasound scans. They resonate in an ultrasound beam, contracting and expanding as pressure changes occur in the ultrasound...

2012年11月23日 · Microbubbles are used for contrast ultrasound imaging as blood-pool agents in cardiology and radiology. Their promise as targeted agents for molecular imaging is now being recognized. Microbubbles can be functionalized with ligand molecules that bind to molecular markers of disease.

2004年6月1日 · Ultrasound-mediated destruction of gene-laden microbubbles has been shown to enhance tissue deposition of plasmid and viral vector DNA and to enhance transfection efficiency 41,42,43.

2016年3月5日 · Ultrasound contrast agents in current use are typically small (3–5 μm diameter) gas-filled bubbles, which are slightly smaller than an erythrocyte (Fig. 17-1). Microbubble contrast agents are physiologically inert, non-toxic and pass through the pulmonary circulation following intravenous injection.