(a) The AFM-based cell balance (picobalance) uses a resonating microcantilever. A blue laser photothermally actuates the microcantilever at its fixed end. The infrared laser, which is...

Here, we modify a previously described cell balance (‘picobalance’) to monitor the proliferation of single cells of the budding yeast, Saccharomyces cerevisiae, under culture conditions in ...

2017年10月26日 · Here, we introduce a picoscopic cell balance that can be used to non-invasively measure adherent cells at high mass and time resolution. The balance, which is based on an actively actuated silicon...

2023年5月16日 · In this paper, we propose monolithically integrated microcantilever aptasensors based on partially depleted (PD) silicon-on-insulator (SOI) CMOS technology, in which both the piezoresistive...

2017年11月14日 · Daniel Müller and colleagues have developed a picobalance that can measure the mass of a single cell with a temporal resolution high enough to follow mass fluctuations on the millisecond ...

Combined with optical microscopy to monitor the yeast morphology and cell cycle phase, the picobalance approaches a total mass resolution of 0.45 pg. Our results show that single budding yeast cells (S/G2/M phase) increase total mass in multiple linear segments sequentially, switching their growth rates.

Microcantilevers are a traditional but crucial MEMS design used for sensing, imaging, and time-keeping applications. This paper presents a thorough review of how the complex dynamical response of the microcantilever excited by a periodic force and interacting with the surrounding environment can be used for mass and rheological sensing.

2023年1月6日 · (a) The AFM-based cell balance (picobalance) uses a resonating microcantilever. A blue laser photothermally actuates the microcantilever at its fixed end. The infrared laser, which is reflected from the free end of the microcantilever onto a photodiode, measures the cantilever deflection and resonance frequency.

Daniel Müller and colleagues have developed a picobalance that can measure the mass of a single cell with a temporal resolution high enough to follow mass fluctuations on the millisecond...

A recent study employing an inertial picobalance and microscopy showed that the growth rate of yeast cells in S/G2/M has a non-monotonic pattern similar to the protein synthesis rate dynamics ...