Microglia in Pain: Detrimental and protective roles in …
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Microglia in neuropathic pain: cellular and molecular ... - Nature
2018年2月8日 · Over recent decades, studies have provided evidence for the necessity and sufficiency of microglia for the alterations in synaptic remodelling, connectivity and network function that underlie...
Microglia in Pain: Detrimental and Protective Roles in
2018年12月19日 · Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Review Microglia in Pain: Detrimental and Protective Roles in ...
2018年12月19日 · Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Microglia in neuropathic pain: cellular and molecular ... - PubMed
Over recent decades, studies have provided evidence for the necessity and sufficiency of microglia for the alterations in synaptic remodelling, connectivity and network function that underlie chronic pain and have shed light on the underlying molecular and cellular mechanisms.
Microglia in Pain: Detrimental and Protective Roles in …
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Microglia role in the pain phenomenon - PMC - National Center …
2023年12月22日 · We now know that signaling molecules are altered in microglia and contribute to the pathogenesis of pain; microglial mediators such as pro- and anti-inflammatory cytokines are potent neuromodulators that regulate synaptic transmission and pain via neuron-glial interactions; and microglia have an emerging role in pain resolution, in part via ...
Microglia in the spinal cord and neuropathic pain - PMC
Spinal Microglia are Crucial for Neuropathic Pain. Activated microglia show dramatic changes in the expression of various genes, including cell‐surface receptors for neurotransmission (e.g., purinergic receptors) and intracellular signaling molecules (e.g., mitogen‐activated protein kinases [MAPKs]) and bioactive diffusible factors (e.g ...
Role of microglia in neuropathic pain, postoperative pain, and …
An important progress in pain research points to important role of microglial cells in the development of chronic pain. Spinal cord microglia are strongly activated after nerve injury, surgical incision, and chronic opioid exposure.
Microbes, microglia, and pain - PMC - National Center for …
2020年1月29日 · Microglia, the resident macrophages of the central nervous system (CNS), are critically involved in the initiation and persistence of chronic pain. Microglia respond to local signals from the CNS but are also modulated by signals from the gastrointestinal tract.