A recent ultrastructural analysis using high-resolution transmission electron microscopy (TEM) revealed a unique phenotype of microglia known as ‘dark microglia’ (DM), which is named for …

Recent TEM studies have uncovered a new microglial phenotype, named dark microglia. These dark microglia share many ultrastructural characteristics (including cell size, …

2019年2月13日 · Single-cell analysis of tissues of the central nervous system during homeostasis in mice revealed specific time- and region-dependent subtypes of microglia. Demyelinating …

2021年4月15日 · Our findings reveal that the TAM system is an essential mediator of microglial recognition and engulfment of amyloid plaques and that TAM-driven microglial phagocytosis …

2024年6月18日 · Transmission electron microscopy (TEM) revealed that CSDS led to the expansion of the ER and swelling of mitochondria in microglia (Fig. 1e), indicating that...

2018年12月4日 · TEM studies were successful in defining a set of morphological criteria for microglia: a polygonal nucleus with peripheral condensed chromatin, a relatively small …

2024年10月1日 · In this review we outline recent advances in TREM2 biology and its implications for microglial function, with particular emphasis on findings from iPSC-derived microglia (iMG) …

2018年4月25日 · In this mini-review, we will focus on defining the distinctive ultrastructural features of microglia and the unique insights into their function that were provided by EM. …

2022年6月29日 · In this review, we offer an overview of microglial morphological analysis methods, exploring the advantages and disadvantages of each, highlighting a number of key …

Using transmission electron microscopy (TEM) we recently characterized a microglial phenotype that is induced by chronic stress, fractalkine receptor deficiency, aging, or Alzheimer disease …