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2023年12月29日 · MRG003在中国的关键注册性IIb期临床试验旨在研究及评估其就治疗R/MNPC的安全性、初步疗效及MRG003的最佳剂量策略，并积累更多数据以全面评估后期临床试验的风险及效益，从而加快该产品的全球开发进程。 MRG003是一种由EGFR靶向单克隆抗体与强效的微管抑制有效载荷一甲基澳瑞他汀E分子通过缬氨酸－ 瓜氨酸链接体偶联而成的ADC。 其以高亲和力特异性地结合肿瘤细胞表面的EGFR，通过内吞及溶酶体蛋白酶裂解后释放强效的有效载荷，从而 …

2022年7月1日 · Importance: The antibody drug conjugate drug MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 monoclonal antibody that is conjugated with monomethyl auristatin E via a valine-citrulline linker. There is currently insufficient evidence of this drug's safety and efficacy.

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There is an unmet need for more effective treatments in recurrent/metastatic nasopharyngeal carcinoma (r/m NPC) after chemo- and immune-therapy. MRG003 is a novel ADC composed of a humanized anti-EGFR mAb conjugated to MMAE via a vc-linker. Here we report the primary dose finding study results of MRG003 in r/m NPC.

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MRG003 is a novel ADC composed of a humanized anti-EGFR mAb conjugated to MMAE via a vclinker. MRG003 is presently being investigated in an ongoing Ph I study. In the Ph Ia dose escalation with 3+3 design, pts with advanced cancers …

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DeepMRG is a multi-label deep learning classifier for predicting bacterial metal resistance genes (MRGs). It can be used to predict MRGs from protein sequences provided in fasta file. It also can be applied on metagenomic or isolate assembled contigs (in fasta) to predict MRGs. This Github is the local version of DeepMRG.