mk8722 (mk-8722) 是所有 12 种哺乳动物 ampk 复合物的有效、直接、变构激活剂。 MK8722 激活 pAMPK 复合物，与 AMP 相比具有更高的效力和幅度，EC 50 值为 ~1 至 60 nM，激活增加了 ~4 至 24 倍。

2017年8月4日 · We developed MK-8722, a potent, direct, allosteric activator of all 12 mammalian AMPK complexes. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia.

MK8722 (MK-8722) is a potent, direct, allosteric activator of all 12 mammalian AMPK complexes. MK8722 activates pAMPK complexes with increased potency and magnitude versus AMP, with EC 50 values of ~1 to 60 nM and increased activation by factors of ~4 to 24.

2017年7月13日 · We developed MK-8722, a potent, direct, allosteric activator of all 12 mammalian AMPK complexes. In rodents and rhesus monkeys, MK-8722–mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia.

Western blotting 证实 MK8722 通过 FASN 依赖性脂质代谢重编程，在激活上游自噬 (PI3K/AKT/mTOR) 和抑制下游自噬中发挥作用。 质粒瞬时转染证明 MK8722 通过阻断自噬体-溶酶体融合来抑制晚期自噬。

简介： MK8722 是一种有效的全身pan-AMPK激活剂。相比AMP（EC50：约1~60nM），MK8722对pAMPK复合物的激活力和效率更高，激活程度可以提高约4~24倍。 物理性状及指标： 外观：……………………白色至类白色固体. 溶解性：…………………DMSO：31.25mg/mL

2024年1月1日 · Western blotting confirmed that MK8722 plays a role in activating autophagy upstream (PI3K/AKT/mTOR) and inhibiting autophagy downstream via FASN-dependent reprogramming of lipid metabolism. Plasmid transient transfection demonstrated that MK8722 suppressed late-stage autophagy by blocking autophagosome-lysosome fusion.

2017年12月1日 · We describe the optimization of β1-selective, liver-targeted AMPK activators and their evolution into systemic pan-activators capable of acutely lowering glucose in mouse models.

Background: MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. This study tried to explore the underlying anti-cancer molecular mechanism of MK8722 in human pancreatic cancer cells (PCCs).

简介:MK8722 是一种有效的全身pan-AMPK 激活剂。 相 比AMP(EC50:约 1~60nM),MK8722 对pAMPK复合物的激活力和效率更高, 激活程度可以提高约4~24 倍。 有机溶剂残留:............ 符合ICH及中国药典规定. 我司产品为非无菌包装,若 用于细胞培养,请 提前做预处理( 如0.22μm 滤膜过滤),除 去热原细菌,否则会导致染菌。 溶解性是在室温下测定的, 如果温度过低, 可能会影响其溶解性。 科研试剂, 广泛应用于分子生物学、 药理学等科研方面, 严禁用于人体。 为了您的安全和 …