
经典信号通路总结——MAPK信号通路 - 知乎 - 知乎专栏
mapk通路有4种主要的分支路线: erk 、 jnk 、 p38 /mapk和erk5。 其中,JNK和p38功能相似,跟炎症、凋亡、生长都有关;ERK主要管细胞生长、分化,其上游信号是著名的 Ras/Raf …
Structure and dynamics of the MKK7–JNK signaling complex
2015年3月3日 · MKK7 activates the c-Jun N-terminal kinase (JNK) pathway and is the only MKK containing three motifs within its regulatory domain. Here we obtain a comprehensive picture …
Diverse Roles of JNK and MKK Pathways in the Brain - PubMed
The c-Jun NH(2)-terminal protein kinase (JNK) plays important roles in a broad range of physiological processes. JNK is controlled by two upstream regulators, mitogen-activated …
The bottleneck of JNK signaling: Molecular and functional ...
2011年6月1日 · The central question is how two MKKs regulate or affect the multiple actions of their JNK substrates. Similar to JNKs, MKK4 and MKK7 can simultaneously exert divergent …
层层进击的磷酸化信号—MAPK通路解析 (下) - 知乎
JNK/SAPK (c-Jun kinase/stress activated protein kinase)级联反应能被UV辐射、热激或者炎症因子激活。 如下图,举例其中一个途径: 这类MAPK通路可以由两种小G蛋白Rac和Cdc42介导。
MAPK-JNK Signaling Pathway_信号通路_Elabscience伊莱瑞特【官 …
JNK又被称为应激活化蛋白激酶(stress-activated protein kinase, SAPK),是哺乳类细胞中MAPK(Mitogen-activated Protein Kinase,丝裂原活化蛋白激酶)信号通路的另一亚类 …
JNK信号通路:治疗神经退行性疾病的新希望? - 知乎专栏
研究发现,ad患者死后的大脑样本中,磷酸化jnk(p-jnk)水平升高,并且与aβ呈正相关。 JNK会调节淀粉样前体蛋白(APP)的功能和代谢,促使APP快速转运到细胞表面并磷酸化,最终 …
JNK信号传递的瓶颈:MKK4和MKK7的分子和功能特征 ... - X-MOL
2011年2月22日 · 促分裂原活化蛋白激酶(MKK)4和7的功能通常与c-Jun N端激酶(JNK)信号通路相关。 两种MKK协同磷酸化不同的JNK同工型,因此参与许多生理过程(例如分化和增 …
The bottleneck of JNK signaling: molecular and functional ...
The functions of mitogen-activated protein kinases (MKKs) 4 and 7 are typically associated with the c-Jun N-terminal kinase (JNK) signaling pathway. Both MKKs synergistically phosphorylate …
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
2001年7月19日 · We find that the TAK1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF6 and Ubc13–Uev1A. Moreover, the activity of TAK1 to …