2024年12月25日 · MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with MKNK1 include Glioma Susceptibility 1 and Leukemia, Acute Myeloid. Among its related pathways are Negative regulation of …

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. [5][6] MKNK1 has been shown to interact with MAPK1 [7] and Eukaryotic translation initiation factor 4 gamma. [8] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

MNK-1 controls chemokine secretion and proliferation in human airway smooth muscle cells. MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 and p38 mitogen-activated protein kinase, a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.

Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues. 该基因编码的 Ser/Thr 蛋白激酶与 ERK1 和 p38 丝裂原活化蛋白激酶相互作用并被其激活，因此可能在对环境压力和细胞因子的反应中发挥作用。 该激酶还可以通过与 eIF4G 的 C 末端区域相互作用磷酸化 eIF4E 来调节转录。 已经注意到该基因的可变剪接转录物变体。 [RefSeq 提供，2012 年 1 月]

Title: Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice. Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase.

背景：MNK1和MNK2是与MAP激酶相互作用的丝氨酸/苏氨酸激酶，被RAS和MAPK信号通路激活，并参与蛋白质翻译的调控。 两种激酶都会在保守的丝氨酸209上磷酸化翻译起始因子eIF4E …

该基因编码一种丝氨酸-苏氨酸蛋白激酶，可被细胞外信号调节激酶或 p38 丝裂原活化蛋白激酶激活，它可能在细胞因子和环境应激反应中发挥作用。 这种激酶是真核翻译起始因子 4E 磷酸化所必需的，但它不是发育过程中细胞生长所必需的。 该基因的可变剪接导致多个转录变体。 [RefSeq 提供，2013 年 10 月]

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

View mouse Mknk1 Chr4:115696395-115736447 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

2023年4月1日 · Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5′-cap binding protein, eukaryotic translation initiation factor (eIF) 4E.