The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. Some MLVs may infect other vertebrates. MLVs include both exogenous and endogenous viruses.

Moloney Murine Leukemia Virus (MoMuLV or MMLV) integrates into the host genome and is present in infected cells as a DNA provirus. Cell division is required for infection. Virus is not lytic.

全称是 Moloney Murine Leukemia Virus Reverse Transcriptase (莫洛尼鼠白血病病毒逆转录酶)，缩写为M-MLV RT。 M-MLV本质是一种将单链RNA、DNA或RNA-DNA杂合体（利用引物）合成互补DNA链的DNA聚合酶。

鼠白血病病毒（MLV或MuLV）是感染老鼠的逆转录病毒，它可以在老鼠中引起白血病，一些 MLV 可能会感染其他脊椎动物。 MLV有两种——外源性病毒和内源性病毒。 MLV 具有正义单链 RNA (ssRNA) 基因组，该基因组通过逆转录过程通过 DNA 中间体进行复制。 分类. 鼠白血病病毒是属于逆转录病毒家族丙型逆转录病毒 (Gammaretrovirus)的逆转录病毒。 复制 MLV 的病毒颗粒具有 C 型形态，由电子显微镜确定。 MLV 包括外源性和内源性病毒。 外源形式作为新的感染从一个 …

A virus can be viewed as a rather regular, relatively simple physical object. Alternatively, it can be seen as a living organism, evolving in response to selective pressures. Both views are correct! This paper will outline very briefly some of the characteristics of murine leukemia viruses (MLVs), keeping both views in mind.

Moloney murine leukemia virus (MMLV) is a simple retrovirus that can integrate its genetic material into the genome of actively dividing cells or into cells with a disrupted nuclear membrane. From: Trends in Biotechnology, 2002

2021年2月15日 · Moloney murine leukemia virus (MMLV) reverse transcriptase (RT) is widely used in research and clinical diagnosis. Improvement of MMLV RT thermostability has been an important topic of research for increasing the efficiency of cDNA synthesis. In this study, we attempted to increase MMLV RT thermosta …

2021年1月1日 · To date, the most commonly used reverse transcriptase is the enzyme from Moloney murine leukemia virus, M-MuLV RT. Since its discovery, M-MuLV RT has become indispensable for modern RNA studies; the range of M-MuLV RT applications is vast, from scientific tasks to clinical testing of human pathogens.

Encapsidation of the Moloney murine leukemia virus (MMLV) genome is mediated through a specific interaction between the major viral structural protein, Gag, and an RNA packaging signal, Ψ.

2016年4月6日 · To characterize Moloney murine leukemia virus (MMLV) reverse transcriptases (RTs) expressed in a cell-free system and in Escherichia coli. We previously expressed MMLV RT using an E. coli expression system and generated a highly thermostable quadruple variant MM4 (E286R/E302K/L435R/D524A) by site-directed mutagenesis.