Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. [5] [6] It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive …

Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the …

In this review, we summarize the recent progress of selective MMP-13 inhibitors including two subfamilies, namely zinc-binding and non-zinc-binding selective MMP-13 inhibitors. Keywords: …

2014年11月7日 · MMP13, which is expressed by epithelial and inflammatory cells, is able to locally activate pro-tumour necrosis factor (pro-TNF) into soluble TNF (sTNF), resulting in …

2013年1月8日 · The purpose of this study was two-fold: 1) to investigate the role of MMP13 in the development of OA; and 2) to evaluate the efficacy of the MMP13 inhibitor CL82198 as a …

2018年4月1日 · The various studies that focused on the enzyme and insights about the structure, activation and inhibition of MMP13 gene have been discussed. The molecular mechanism …

2024年12月25日 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and …

2013年1月8日 · Matrix metalloproteinase (MMP) 13 is a major enzyme that targets cartilage for degradation. Compared to other MMPs, the expression of MMP13 is more restricted to …

2019年2月16日 · In a recent publication, Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase (MMP) 13 (also called Collagenase 3) in AD pathogenesis through …

Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at …