Mouse Models Enable the Functional Investigation of Tertiary …
Herein, we discuss critical aspects to consider when modeling TLSs and describe recent findings of TLS studies in the mouse lung and intestinal gut environments as examples to highlight the …
Frontiers | Of mice and lymphoid aggregates: modeling tertiary …
2023年10月25日 · Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and …
Tertiary lymphoid structures in cancer | Science - AAAS
Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory …
Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor …
Mouse models of colon cancer demonstrate the capacity for TLS to form. In a colitis-associated colon cancer model, TLS were analyzed and found to contain the expected aggregation of …
Tertiary Lymphoid Structures and B cells: Clinical impact and ...
2020年4月1日 · This review encompasses the characteristics and functions of TLS and of B cells in human tumors, their prognostic and theranostic impact and summarizes the mouse models …
Therapeutic Induction of Tertiary Lymphoid Structures in Cancer …
Therapeutic TLS induction in cancer patients holds the promise to advance immunotherapy. Numerous attempts have been made to induce TLS in mouse models, so far with mixed …
Tertiary lymphoid structures in cancer: maturation and induction
2024年4月15日 · Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated …
Immune mechanisms orchestrate tertiary lymphoid structures …
2021年7月20日 · Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced patient survival and responsiveness to cancer therapies, but the mechanisms …
Induction of Tertiary Lymphoid Structures With Antitumor ... - PubMed
2018年7月16日 · Tertiary lymphoid structures (TLSs) associate with better prognosis in certain cancer types, but their underlying formation and immunological benefit remain to be …
Tertiary lymphoid structures in the era of cancer immunotherapy
2019年5月15日 · Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key common...