MreB 是一种 原核细胞骨架，是 真核生物 肌动蛋白 的原核 同源 物 [1]。 几乎所有的非球形细菌都依赖MreB来确定它们的形状。 MreB在 细胞质膜 下组装成丝状结构的螺旋网络，覆盖细胞的整个长度 [2]。 MreB通过介导合成 肽聚糖 的酶的位置和活性来确定细胞形状，并通过作为细胞膜下的刚性细丝起作用，施加向外的压力来雕刻和支撑细胞 [3]。 MreB从其正常的螺旋网络凝结，并在细胞分裂前在 新月柄杆菌 （Caulobacter crescentus）的隔膜（septum）处形成紧密环，这是 …

MreB is a protein found in bacteria that has been identified as a homologue of actin, as indicated by similarities in tertiary structure and conservation of active site peptide sequence. The conservation of protein structure suggests the common ancestry of the cytoskeletal elements formed by actin, found in eukaryotes , and MreB, found in ...

2018年7月18日 · An unbiased machine learning analysis shows that MreB polymer number, the total length of MreB polymers, and MreB curvature preference are key correlates of cylindrical uniformity, the...

mreB基因突变的球形菌中，染色体分离受到影响，出现了染色体缺失的球状体 。结果提示，MreB蛋白与细菌染色体分离相关 。Wachi等发现MreB蛋白的抑制剂A22能快速干扰MreB蛋白的多聚化和胞内定位，导致细菌杆状形态丢失甚至死亡 [9-10] 。

2022年5月2日 · MreB, the bacterial ancestor of eukaryotic actin, is responsible for shape in most rod-shaped bacteria. Despite belonging to the actin family, the relevance of nucleotide-driven polymerization dynamics for MreB function is unclear. Here, we provide insights into the effect of nucleotide state on mem …

FtsZ 能在 细胞分裂 位点装配形成Z 环结构，并通过该结构参与细胞分裂的调控；MreB能形成螺旋丝状结构，其主要功能有维持细胞形态、调控 染色体分离 等；CreS存在于 新月柄杆菌 中，它在细胞凹面的 细胞膜 下面形成弯曲丝状或螺旋丝状结构，该结构对维持 ...

2014年3月7日 · Here we show that the bacterial actin homologue MreB displays a comparable activity. MreB forms membrane-associated filaments that coordinate bacterial cell wall synthesis. We noticed that the...

Here, we review general principles that have surfaced by the study of rod-shaped bacterial growth. Imaging approaches have revealed that polymers of the actin homolog MreB play a central role. MreB both senses and changes cell shape, thereby generating a self-organizing feedback system for shape maintenance.

MreB 可以感知并改变细胞形状，从而生成用于形状维持的自组织反馈系统。 在分子水平上，结构和计算研究表明，MreB 丝表现出可调节的机械性能，这解释了它们对沿着圆柱形细胞体的某些几何形状和方向的偏好。

MreB is a filamentous actin homolog that forms a helical bundle directly underneath the inner membrane of rod-like bacterial cells. You might find these chapters and articles relevant to this topic.