2024年12月25日 · MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency, Nuclear Type 1 and Mitochondrial Myopathy, Encephalopathy, Lactic …

The MT-CO2 gene encodes for the second subunit of cytochrome c oxidase (complex IV), a component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. MT-CO2 is one of the three subunits which are responsible for the formation of the functional core of the cytochrome c oxidase .

2025年1月2日 · Here, we show that glucose deprivation upregulates the expression of mitochondrial-cytochrome c oxidase II (MT-CO2), a subunit essential for the respiratory chain complex IV, in...

MT-CO1 and MT-CO2 are two copper binding subunits of complex IV, which transfers electrons from CYCS (cytochrome c, somatic) and drives the electrochemical production of adenosine triphosphate (ATP) . Thus, cellular copper pools are closely linked to mitochondrial oxidative phosphorylation.

MT-CO2 gene: Along with the senescence of HMSCs, MT-CO2 gene methylation increased and its protein expression level significantly decreased. Treatment with 5-aza-2’-deoxycytidine inhibited COX2 methylation.

2025年2月9日 · MT-CO2 mutation m.8088delT resulting in a premature stop codon was identified in a patient with myopathy and perturbed acylcarnitine profile. Title: Mitochondrial complex IV deficiency caused by a novel frameshift variant in MT-CO2 associated with myopathy and perturbed acylcarnitine profile.

2024年12月10日 · Clinical resource with information about MT-CO2, MELAS syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Complete sequencing of the mitochondrial DNA genome in muscle identified a novel MT-CO2 variant, m.8163A>G predicting p.(Tyr193Cys). We present several lines of evidence, in proving the pathogenicity of this heteroplasmic mitochondrial DNA variant, as the cause of …

Cytochrome c oxidase subunit II (COII or MTCO2) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation.

2020年2月25日 · Considerable evidence suggests that mitochondrial DNA mutations are associated with heart failure. In this work, we examined the possible mutations in hotspot mitochondrial genes and their association with Iranian patients with coronary artery disease.