MT-ND4L is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 4L (ND4L) protein. [5] The ND4L protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. [6]

2024年12月25日 · MT-ND4L (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4L) is a Protein Coding gene. Diseases associated with MT-ND4L include Leber Hereditary Optic Neuropathy, Modifier Of and Mitochondrial Disease. Among its related pathways are Electron transport chain: OXPHOS system in mitochondria and Complex I biogenesis.

2021年7月19日 · 呼吸链复合物I亚基由核DNA和mtDNA共同编码，mtDNA编码的复合物I亚基ND1、ND2、ND3、ND4、ND4L、ND5、ND6都会发生突变导致Leber's Heredity Optic Neuropathy（成人视神经退行性疾病），MELAS，Leigh syndrome，MERRF（儿童神经退行性疾病）等恶性疾病。

Specifically, seven of these genes (MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6) encode for subunits of complex I; one gene encodes for cytochrome b (MTCYB), which represents a subunit of complex III; three genes encode for cytochrome I, II, III, which are part of the complex IV (MT-CO1, MT-CO2, MT-CO3), and finally two genes encode ...

The MT-ND4L gene provides instructions for making a protein called NADH dehydrogenase 4L. This protein is part of a large enzyme complex known as complex I, which is active in …

Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.

中文名称：线粒体编码的 NADH 4L 脱氢酶 种属: Homo sapiens 同用名: MTND4L; ND4L

2024年12月10日 · Gene target information for ND4L - NADH dehydrogenase subunit 4L (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Enables NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion.

2024年6月26日 · Clinical resource with information about MT-ND4L, Leber optic atrophy, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.