2022年9月15日 · Here, we identified a novel lncRNA, MTAR1, which is critical for post-transcriptional regulation of MYC-induced tumorigenesis. MTAR1 is essential for recruiting IGF2BPs into PABP1-mediated...

Here, we identified a novel lncRNA, MTAR1, which is critical for post-transcriptional regulation of MYC-induced tumorigenesis. MTAR1 is essential for recruiting IGF2BPs into PABP1-mediated liquid-liquid phase separation (LLPS) complexes and …

2022年9月15日 · Here, we identified a novel lncRNA, MTAR1, which is critical for post-transcriptional regulation of MYC-induced tumorigenesis. MTAR1 is essential for recruiting IGF2BPs into PABP1-mediated liquid–liquid phase separation (LLPS) complexes and facilitates IGF2BPs-mediated MYC mRNA translation.

LncRNA MTAR1 can bind with IGF2BPs and help facilitate recruitment of PABP1 and MYC mRNA to form a complex. PABP1 is a scaffold protein that can induce LLPS. When IGF2BPs are recruited into...

Here, we identified a novel lncRNA, MTAR1, which is critical for post-transc... Natural antisense transcripts (NATs or AS transcripts) are frequently transcribed from many eukaryotic genes and...

2025年1月11日 · 一种新的lncRNA MTAR1通过IGF2BPs介导的c-MYC转录后调节促进癌症发展

2022年9月15日 · Here, we identified a novel lncRNA, MTAR1, which is critical for post-transcriptional regulation of MYC-induced tumorigenesis. MTAR1 is essential for recruiting IGF2BPs into PABP1-mediated...

A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC 来自 国家科技图书文献中心 喜欢 0

Here, we identified a novel lncRNA, MTAR1, which is critical for post-transc... Natural antisense transcripts (NATs or AS transcripts) are frequently transcribed from many eukaryotic genes and...

2022年5月21日 · By regulating the bioavailability of the type-1 IGF receptor (IGF1R) ligands, IGF-1 and IGF-2, the IGF binding proteins (IGFBP-1 to -6) play essential roles in cancer progression. IGFBPs also...