Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. [5][6] This gene encodes a member of the mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces. [5]

粘液中主要的糖蛋白是Mucin-2（MUC2），同时含有O-和N-连接的聚糖。先前有研究表明，糖基化的MUC2能维持屏障的完整性，但预防IBD的关键糖型还不清楚。 先前有研究表明，糖基化的MUC2能维持屏障的完整性，但预防IBD的关键糖型还不清楚。

Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production.

2020年6月11日 · 摘要: 哺乳动物肠道分泌大量黏液形成黏液层，其主要成分是黏蛋白2（MUC2）。 黏液层对肠道的润滑、保护及强大的屏障功能依赖于MUC2自身的特殊网状结构、性质与功能。 肠道MUC2的存在对维系肠腔微环境稳定和肠上皮细胞功能正常具有重要作用。 本文综述了肠道MUC2的分泌、结构、合成调控及其在肠道疾病发生发展中的作用，为经调控MUC2防治肠道疾病提供理论依据。 Corresponding author: WEN Zhengshun, associate professor, E …

本文介绍 muc2（黏蛋白 2），含同义缩写、阳性定位等基本信息，阐述其在胃肠道、卵巢肿瘤研究中的应用，及联合相关抗体鉴别胃肠道肿瘤等情况。 资讯

2024年12月25日 · MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC2 include Pseudomyxoma Peritonei and Gastric Cancer. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins. An important paralog of this gene is MUC5B.

Mucin 2 (MUC2) is a high-molecular weight glycoprotein that serves as the major structural component of the protective mucus layer in the gastrointestinal tract, produced by goblet cells in the colon and small intestine.

摘要： 黏蛋白-2 (MUC2)是肠黏液层主要成分，覆盖于肠上皮细胞顶端，主要由杯状细胞分泌，在润滑肠道、为肠内抗菌蛋白及共生菌群提供黏附位点、抵御肠内致病菌及有害物质入侵等方面发挥着重要功能。 近年来MUC2在肠道黏膜屏障损伤中的作用研究日趋受到学者重视，这也可能是肠黏膜屏障损伤的一个重要治疗突破口。 Abstract: Mucin-2 (MUC2), secreted by goblet cells of the intestine, covers the gastrointestinal tract and is the most abundantly expressed mucin in the …

mucin-2, mucin 2, intestinal/tracheal. GeneRIFs: Gene References Into Functions. The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking. REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.

Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight.