
Mucin 4 - Wikipedia
Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These ...
MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer ...
MUC4, a high molecular weight glycoprotein that functionally contributes to PC pathogenesis, is an attractive TAA. It is not detected in the normal pancreas; however, it is overexpressed in mouse and human pancreatic tumors.
MUC4 Gene - GeneCards | MUC4 Protein | MUC4 Antibody
2024年12月25日 · MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include Biliary Tract Cancer and Adenosquamous Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.
Mucins: Structural diversity, biosynthesis, its role in …
2018年2月1日 · Mucin 4 is a cell surface associated mucin encoded by MUC4 gene and is localized to chromosome locus 3q29 (Gross et al., 1992). Mucin 4 expression has been detected in bronchus, endocervix, prostate ( Porchet et al., 1995 ) and conjunctival epithelium ( Gipson and Inatomi, 1997 ), with weak expression in colon, gastric epithelium and small ...
Structure, evolution, and biology of the MUC4 mucin - PMC
MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.
MUC4 - mucin 4, cell surface associated Gene - MCE-生物活性分 …
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation.
Characterization of recombinant β subunit of human MUC4 mucin …
2021年12月9日 · MUC4 is a transmembrane mucin expressed on various epithelial surfaces, including respiratory and gastrointestinal tracts, and helps in their lubrication and...
MUC4 mucin 4, cell surface associated [ (human)] - National …
The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis; MUC4 has a role in promoting neural invasion mediated by the axon guidance factor Netrin-1 in pancreatic ductal adenocarcinoma
Membrane Mucin Muc4 promotes blood cell association with …
2017年9月11日 · Mucin-4 (Muc4) is a large cell surface glycoprotein, composed of a heavily O-glycosylated extracellular alpha subunit and a membrane-anchored beta subunit that normally functions to...
MUC4 mucin 4, cell surface associated [ Homo sapiens (human) ]
2025年2月8日 · Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. Vincent A, et al .