Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These ...

MUC4, a high molecular weight glycoprotein that functionally contributes to PC pathogenesis, is an attractive TAA. It is not detected in the normal pancreas; however, it is overexpressed in mouse and human pancreatic tumors.

2024年12月25日 · MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include Biliary Tract Cancer and Adenosquamous Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

2018年2月1日 · Mucin 4 is a cell surface associated mucin encoded by MUC4 gene and is localized to chromosome locus 3q29 (Gross et al., 1992). Mucin 4 expression has been detected in bronchus, endocervix, prostate ( Porchet et al., 1995 ) and conjunctival epithelium ( Gipson and Inatomi, 1997 ), with weak expression in colon, gastric epithelium and small ...

MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation.

2021年12月9日 · MUC4 is a transmembrane mucin expressed on various epithelial surfaces, including respiratory and gastrointestinal tracts, and helps in their lubrication and...

The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis; MUC4 has a role in promoting neural invasion mediated by the axon guidance factor Netrin-1 in pancreatic ductal adenocarcinoma

2017年9月11日 · Mucin-4 (Muc4) is a large cell surface glycoprotein, composed of a heavily O-glycosylated extracellular alpha subunit and a membrane-anchored beta subunit that normally functions to...

2025年2月8日 · Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. Vincent A, et al .