Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene [5] [6] [7] [8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus.

2019年11月22日 · The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective barrier.

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7] MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.

2018年2月1日 · Mucin 5AC is the major mucus component in the normal respiratory tract epithelium that has an important role in defence against pathogenic and environmental challenges. Mucin 5AC in the gastric mucosa acts as a selective barrier for HCl diffusion.

Mucin 5B is a secreted gel forming mucin encoded by MUC5B gene that is located in the chromosome locus 11p15.5. It is a major human airway mucin produced in the mucous cells of submucosal gland and glandular ducts (Buisine, 1999). It is also known as high-molecular weight salivary mucin MG1 or human gallbladder mucin.

2024年12月25日 · MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include Interstitial Lung Disease 2 and Extrinsic Allergic Alveolitis. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins. An important paralog of this gene is MUC5AC.

2025年2月8日 · The MUC5B (mucin 5B, oligomeric mucus/gel-forming) gene encodes respiratory tract mucin glycoproteins that play a role in mucociliary clearance and host defense. Level of Mucin 5B was significantly higher in serum of oral lichen planus (OLP).

Mucin 5 subtype B, also known as MUC5B, is a high molecular weight glycoprotein that belongs to the mucin family. It is primarily found in the mucus lining of the respiratory tract, where it plays a crucial role in protecting the epithelial cells from pathogens and environmental damage.

2024年1月22日 · Background: MUC5AC is a gel-forming glycoprotein that exists in two major glycoforms in PDA. We studied the differential expression and predictive value of heavily glycosylated mature MUC5AC (MM) detected in the apical (Ap) and/or extracellular region (EC) and less-glycosylated immature MUC5AC (IM) detected only in the cytoplasm (Cy) in R-PDA.

2019年1月17日 · Mucins are high molecular mass, highly glycosylated macromolecules that are the major components of mucus secretions. MUC5B is a salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva. It is composed of 14.9% protein, 78.1% carbohydrate, and 7% sulfate (Troxler et al., 1995).