2024年9月20日 · Mucus is a clear, slippery, gel-like substance that’s part of your immune system. It lines your mucous membranes and helps trap and destroy or clear out germs and harmful particles. Mucus gets thick and sticky and might be white, yellow or green when you have an infection. It’s also called phlegm, snot or sputum.

2021年7月26日 · Mucosal vaccination utilizing nucleic acids poses a greater challenge, as successful candidates must penetrate the mucus layer, translocate into target cells and evade extracellular and ...

In this review, we discuss the impact of vaccine administration in different mucosal surfaces; how appropriate adjuvants enhance the induction of protective mucosal immunity and other factors that can influence the mucosal immune response to vaccines. Keywords: adjuvants; immunization routes; mucosal immunity; mucosal surfaces; vaccine.

2022年6月22日 · Stanford University scientists have implicated a logjam of three long, stringy substances behind deadly thick sputum in COVID-19 patients who need a machine to help them breathe. One of these substances may prove especially amenable to treatment with a drug invented long ago for another purpose. It may also play a role in long COVID.

2023年8月16日 · We applied this technology to develop a mucosal vaccine for severe acute respiratory syndrome coronavirus 2 and found that intranasal vaccination with spike protein–encoding mRNA polyplexes induced potent cellular and humoral adaptive immunity and protected susceptible mice from lethal viral challenge.

2023年6月27日 · The nasal cavity is well-equipped with sticky mucus that traps pathogens and serves as an important site for immune cell surveillance and signaling. It may also be our best ally in the fight against SARS-Cov-2.

Mucosal vaccines can effectively induce an immune response at the mucosal site and form the first line of defense against microbial invasion. The induced mucosal immunity includes the proliferation of effector T cells and the production of IgG and IgA antibodies, thereby effectively blocking microbial infection and transmission.

2024年5月21日 · It cleans your nasal passages, keeps your tissues lubricated, filters out dust and bacteria you might inhale, and helps protect you from infection. Your body makes about a liter (approximately 1...

2024年4月30日 · This month, most of the news is in mucosal vaccine development again. These vaccines aim to block Covid infection. An aerosol vaccine from Canada is advancing into a mid-stage clinical trial. Plus, an intranasal protein subunit vaccine from Australia is going into a first-in-human clinical trial – the 28th mucosal vaccine to do so.

Next generation vaccines must consider formulation and delivery alternatives that enable simpler storage conditions and provide more robust mucosal protection. This represents a significant opportunity for the development of inhaled mRNA vaccines.