MutS、MutL、MutH或MutU的缺失或失效可使E.coli的突变率提高500-1000倍。 现有实验结果表明：在DNA复制过程中，新生链上的 GATC序列 （约每256bp出现一次）在被合成后的短时间 …

DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and …

2022年10月3日 · Highly conserved MutS and MutL homologs operate as protein dimers in mismatch repair (MMR). MutS recognizes mismatched nucleotides forming ATP-bound sliding …

对这些Mut进行功能分析，发现了MutS，MutL和MutH参与错配误别。 如果有错误出现，如上图所示，一条链是新合成的，其中的GATC中的A没有被甲基化，这个时候MutS和MutL会以另外一 …

2021年1月28日 · Using functional MMR assays and systems preventing proteins from sliding, we show that sliding of human MutSα is required not for MMR initiation, but for final mismatch …

2012年1月1日 · MutL is a key component of this system that mediates protein–protein interactions during mismatch recognition, strand discrimination, and strand removal. Hence, it had long …

2007年12月24日 · MutL interacts physically with MutS, enhances mismatch recognition, and recruits and activates MutH. Defects in MutL completely inhibit MMR in E. coli.

MutL is a key component of this system that mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal. Hence, it had long been …

近日，最新研究对DNA 错配修复 （MMR）途径的潜在机制进行了仔细的研究，该机制有助于将基因组保真度维持1000倍以上。 通常，MMR与DNA 复制机制 协同工作，利用两种校对蛋白作 …

The MutL family of DNA mismatch repair proteins plays a critical role in excising and repairing misincorporation errors during DNA replication. In many eukaryotes, members of this family …