ALK is a MYCN target gene and regulates cell migration and
2013年12月20日 · In the present study, we found that ALK directly mediates MYCN-induced oncogenic properties. The promoter region of ALK gene contains a non-canonical E-box …
ALK positively regulates MYCN activity through repression of …
2018年12月11日 · We show that mutant ALK downregulates the ‘HMG-box transcription factor 1’ (HBP1) through the PI 3 K-AKT–FOXO3a signaling axis. HBP1 inhibits both the transcriptional …
ALK in Neuroblastoma: Biological and Therapeutic Implications
The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a th-MYCN transgenic neuroblastoma mouse …
MYCN与ALK基因相关靶向药在神经母细胞瘤治疗试验中的进展
靶向治疗具有特异性强、灵敏度高、毒副作用小等特点，是肿瘤治疗研究的新方向。 本文主要对MYCN基因、ALK基因相关靶向药物在神经母细胞瘤治疗试验中的研究进展进行综述。
ALK and MYCN: when two oncogenes are better than one
Mutations of ALK are frequently observed in MYCN -amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development …
New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK
2013年11月1日 · We review the latest approaches envisioned for blockade of ALK activity in neuroblastoma, present a classification of potential approaches for therapeutic targeting of …
ALK in cancer: from function to therapeutic targeting - Nature
2025年3月7日 · The activation of PI3K–AKT by ALK creates a signalling crosstalk that further potentiates the activity of MYCN, thus possibly explaining why neuroblastomas with ALK …
ALK is a MYCN target gene and regulates cell migration and …
In the present study, we found that ALK directly mediates MYCN-induced oncogenic properties. The promoter region of ALK gene contains a non-canonical E-box located upstream of the …
ALK upregulates POSTN and WNT signaling to drive …
2024年3月26日 · Huang et al. used a human stem cell model to elucidate the mechanism for cooperation between MYCN and ALK. ALK contributes to tumor growth by upregulating the …
The prognostic roles of and correlation between ALK and MYCN …
Our study showed a novel coordinately prognostic role of <i>ALK</i> and <i>MYCN</i> protein expression in neuroblastoma and is the first report to demonstrate the correlation between …