Myoferlin is a protein that in humans is encoded by the MYOF gene. [5] [6] [7] [8] Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin.

Dec 25, 2024 · MYOF (Myoferlin) is a Protein Coding gene. Diseases associated with MYOF include Angioedema, Hereditary, 7 and Hereditary Angioedema With Normal C1inh Not Related To F12 Or Plg Variant. Among its related pathways are Nuclear receptors meta-pathway and Signaling events mediated by VEGFR1 and VEGFR2.

Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing ...

Myoferlin (MYOF) is a member of the myofibroblast protein family with multiple C2 domains [20]. MYOF is highly expressed in skeletal muscle, cardiac muscle, and endothelial cells and plays a crucial role in vesicle transport, cell growth and repair, and …

In this short article, we briefly summarize the latest progress related to MYOF, indicating that small molecule inhibitors targeting the MYOF-C2D domain can selectively inhibit the proliferation and migration of cancer cells, and MYOF may be a promising target for the treatment of …

Feb 9, 2025 · Myoferlin is a key regulator of EGFR activity in breast cancer. Turtoi A, et al. Cancer Res, 2013 Sep 1. PMID 23864327. Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells. Blackstone BN, et al. Am J Physiol Cell Physiol, 2015 Apr 15. PMID 25631868.

As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF-targeted therapy in this malignancy has not been explored.