2017年12月1日 · Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.

The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis.

2022年10月1日 · Skeletal muscle development and regeneration is governed by the combined action of Myf5, MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These transcription factors are expressed in a highly spatio-temporal restricted manner, ensuring the significant functional and metabolic diversity observed between the different ...

Molecular characterization of two of the MRFs (MyoD and Myog) suggests an important distinction between these factors, whereby MyoD establishes an open chromatin structure at muscle-specific genes, whereas Myog drives high levels of transcription of genes within this open chromatin state.

生肌调节因子（myogenic regulatory factors,MRFs）是调控肌肉生成的重要基因,家族中包括MyoD、MyoG、Myf5和Myf6。 MyoD能把多种类型细胞转化为成肌细胞,在肌肉特异基因转录调控中起着总开关作用;MyoG的表达能够控制成肌细胞融合的起始,促使成肌细胞增殖;Myf5协同MyoD在 …

肌细胞生成素 (myogenin,MyoG)是生肌调节因子MRFs (MyoD,MyoG,Myf5和MRF4)家族的一员,它的表达具有控制成肌细胞融合的起始,促使成肌细胞的增殖作用,使单核成肌细胞转变成为多核的肌纤维.因此被认为在MyoD家族中具有中心地位.本文就MyoG基因的结构,定位,作用机制,多态性及其与生产性能的关系等作以下综述. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初 …

Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4. [1] These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif. [2] They dimerize with other HLH containing proteins through an HLH-HLH interaction. [3]

MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, their regulatory factors, such as TLE3, NF-κB, and MRF target genes, including non-myogenic genes such as taste receptors.

2020年12月18日 · During mouse myogenesis, MymX and MymK share similar expression patterns with two members of myogenic regulatory factors (MRFs), MyoD and MyoG (11 – 15). MyoD and the two MRF members, Myf5 and Myf6, are determinants of myogenesis (20 – 22). These myogenic factors display functional redundancy and reciprocal regulations of …