NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established.

Core tip: In this study, we aimed to establish and characterize novel human gastric epithelial cell lines derived from NCI-N87 cells after over-expression of human telomerase catalytic activity. The two most promising NCI-N87-derived clones were shown to be composed of cells with homogenous phenotype, to produce gastric zymogens and to produce and secrete neutral …

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In this study, we employed the human gastric cancer cell NCI-N87 with high expression of Her-2 protein to create a trastuzumab-resistant cell line (NCI-N87/TR) for the first time, analyzed the characteristics of NCI-N87/TR cells and investigated the detailed mechanisms regulating the in vitro resistance of gastric cancer to trastuzumab.

The NCI-N87 cell line is an acid-stable model of the gastric epithelium used to study gastric drug metabolism. The objective of this work was to investigate the uptake, trans-epithelial transport, and anti-inflammatory activity of anthocyanins by the NCI-N87 cell line.

0350 - NCI-N87 [N87].

NCI-N87: Human Lung Adenocarcinoma Epithelial Cell Line Established from the metastatic tumor (liver metastasis) of a caucasian, male patient

Jan 5, 2022 · Cell information for NCI-N87. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

NCI-N87 Cell Line Derived Xenograft NCI-N87 is a human gastric adenocarcinoma cell line that was originally derived from a patient with poorly differentiated adenocarcinoma of the stomach. NCI-N87 cells are characterized by their ability to grow as adherent monolayers and form tumors in immunocompromised mice. These cells also have amplification of the ERBB2 gene, which …

NCI-N87 CDX Model The NCI-N87 cell line originates from human gastric cancer, a malignancy that arises from the lining of the stomach. Gastric cancer is known for its varied histological subtypes and its potential for metastasis, particularly to the peritoneum, liver, and lungs.

The above parameters are from one study. For further information on this cell line and other parameters, including different strains, vendors, implant type and location and/or standards of care, please contact us.

The NCI-N87 cell line is an acid-stable model of the gastric epithelium used to study gastric drug metabolism. The objective of this work was to investigate the uptake, trans-epithelial transport, and anti-inflammatory activity of anthocyanins by the NCI-N87 cell line. The cells formed a coherent monolayer, stable ≤32 days post confluency.

NCI-N87, demonstrating one of the most HER2 amplification of the 3 cell lines examined, displayed a 70% growth inhibition with the lowest concentration of lapatinib when when compared to SNU-216 and SNU-16.

The NCI-N87 cell line cell line in Ubigene’s cell bank has low passages, high activity and good cell condition, with available STR Authentication reports.

Sep 2, 2011 · The objective of this study was to evaluate the human NCI-N87 cell line as a model for gastric permeability drug studies under pH conditions of the st…

Jul 29, 2019 · The NCI-N87 cell line is an acid-stable model of the gastric epithelium used to study gastric drug metabolism.

Name (s) NCI-N87 (NCI-H87) Tissue Stomach Cancer Type Gastric Carcinoma Tissue Status Metastasis Sample Site Liver Cancer Type Details Gastric Tubular Adenocarcinoma (NCIT C5473) GDSC Growth Estimate 2.41 +/- 0.54 (16 replicates)

Apr 3, 2025 · 图2 放射性标记Nbs的制备 四、Nbs的HER2和IgG特异性体外结合 文章通过流式细胞术评估了不同肿瘤细胞系的HER2表达水平，结果NCI-N87 (高表达)、JIMT-1 (中表达)及MKN-45 (低表达)细胞系呈现梯度差异。 为验证177Lu标记Nbs的靶向特异性，对NCL-N87和JIMT-1细胞进行竞争性结合 ...

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As of May 10 the project was awarded to Grading, Bridge and Surfacing. US-77: BR #010 (FAWN CREEK) 2.73 MI E OF THE W JCT OF US-77/K-9 IN MS CO. LGTH IS 0.123 MI. Federal Project Number : BRF-A392 (301) State Project Number : U077-58 KA 3923-01 Proposal Number : 523042161 County: Marshall DBE Goal for This Contract is 4.50% If you have any questions …