2024年12月25日 · NCOA3 (Nuclear Receptor Coactivator 3) is a Protein Coding gene. Diseases associated with NCOA3 include Endometrial Hyperplasia and Breast Cancer. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Transcriptional regulation of white adipocyte differentiation.

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors.

核受体共激活因子 3： 该基因编码的蛋白质是一种核受体共激活因子，可与核激素受体相互作用，增强其转录激活功能。 编码的蛋白质具有组蛋白乙酰转移酶活性，并募集 p300/CBP 相关因子和 CREB 结合蛋白作为多亚基共激活复合物的一部分。 这种蛋白质最初存在于细胞质中，但在磷酸化后转移到细胞核中。 已发现该基因编码不同亚型的几种转录变体。 此外，在编码蛋白的 C 末端发现了一个多态性重复区域。 [RefSeq 提供，2010 年 3 月]

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility. A mutant form of ERalpha associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment. NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss.

2021年3月27日 · ncoa3(又称aib1或src-3)是核激素受体共激活因子家族成员，通过与多种转录因子相互作用调控基因表达。ncoa3最初被证明在乳腺癌中被扩增，并在各种实体肿瘤中具有致癌作用。然而，ncoa3在紫外线介导的黑素瘤发生中所起的作用之前并未得到证实。

本课题拟在人胚胎干细胞中干扰NCOA3，检测多能性相关指标，进行ChIP-Seq和microarray分析，并从翻译后修饰水平阐明NCOA3对多能性的作用及调控机制。 同时探讨NCOA3对重编程的影响及在primed和naive干细胞转化中的作用。

2016年4月25日 · We found that NCOA3 is required for induction of XBP1 during E2 stimulation and uncover a positive feedback regulatory loop that maintains high levels of NCOA3 and XBP1 in breast cancer....

2024年12月10日 · Title: NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways. PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients.

Here, we demonstrated that the nuclear receptor coactivator 3 (Ncoa3) is essential for pluripotency maintenance. Knockdown of Ncoa3 not only compromises the expression of pluripotency markers but also impairs in vitro and in vivo differentiation potential of mouse ESCs.

Ncoa3(nuclear receptor coactivator3)Ncoa3是p160蛋白家族的一员,它是一种核受体辅激活因子,能和包括核受体在内的多种转录因子结合,在转录因子对靶基因的调控中发挥桥梁作用.同时,Ncoa3也有组蛋白乙酰转移酶活性,可以促进基因转录.Ncoa3在许多生理过程中起重要作用,如 ...