2025年3月30日 · NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Diseases associated with NCR1 include Gestational Trophoblastic Neoplasm and Hydatidiform Mole, Recurrent, 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. [5] [6] NCR1 has also been designated as CD335 (cluster of differentiation nomenclature), NKP46, NKp46, NK-p46, and LY94. [7]

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues. 功能概要

Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. The NKp46 and NKp46-ligand interaction contributes to NK cell activation.

NCR1，即自然细胞毒性触发受体1，别名NKp46、CD335、LY94。它是一种免疫球蛋白超家族成员，具有两个细胞外免疫球蛋白样域，属于I型跨膜受体。NCR1由人类19号染色体上的基因编码，位于Leukocyte Receptor Complex (LRC) 区域。

The natural cytotoxicity receptor (NCR) family is constituted by NKp46, NKp44, and NKp30 in humans, which are expressed mainly on natural killer (NK) cells and are encoded by the ncr1, ncr2, and ncr3 genes, respectively.

2024年11月2日 · NKp46 is selectively expressed in aggressive subtypes of primary Gastrointestinal T-cell lymphoma.

2017年1月18日 · We hypothesized that NCR1 inactivation disturbs maturation and angiokine production by uterine natural killer (uNK) cells. Using histological and morphometric approaches, we observed that...

Activating receptors include NKG2D, DNAM-1 and the natural cytotoxicity receptors (NCRs) family, the latter being composed of three molecules: NCR1 (NKp46), NCR-2 (NKp44) and NCR-3 (NKp30) . NCR1 was the first NCR isolated and is a type I-transmembrane receptor that contains 2 Ig-domains and that associates with either CD3ζ or FcμRIγ in ...

Using activating receptor natural cytotoxicity receptor (NCR) 1 deficient (NCR1 gfp/gfp) mice, we found increased numbers of virus-specific CD8 T cells, leading to enhanced virus control during acute LCMV infection.