These 2-deoxy-D-glucose in poly (lactic-co-glycolic acid) nanoparticles not only amplified antitumor effects induced by sorafenib or anti–programmed death-1 antibody, but also …

2021年12月6日 · Glucose and glutamine consumption are increased in mtDNA dysfunction, and so we targeted the use of both in cells carrying the pathogenic m.3243A>G variant with 2 …

2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。 * Please select Quantity before adding items. • …

2019年3月11日 · 2-Deoxyglucose (2-DG) is a glucose analog that inhibits glycolysis 9, 10. 2-DG can compete with glucose to bind hexokinase (the first rate-limiting enzyme of glycolysis) in …

2002年9月23日 · To exploit nutrient deprivation as anti-cancer therapy, we investigated the effects of the anti-metabolite 2-deoxy-D-glucose on breast cancer cells in vitro. This compound has …

Results: The 2DG-PLGA-NPs induced cytotoxic effects and antitumor immunity through enhanced T-cell trafficking. In addition, 2DG-PLGA-NPs induced decreased lactate production and …

2012年2月15日 · The inhibitor of glycolysis and N-linked glycosylation, 2-deoxy-d-glucose (2DG), potently inhibited surface expression of MICA/B after histone

2-Deoxy-D-glucose (2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和 糖酵解抑制剂，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 磷酸葡萄糖异构酶 （将葡萄糖转化为 6-磷酸的酶） …

The ability of 2-deoxy- d -glucose (2-DG) to interfere with d -glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and …

2021年1月1日 · It is necessary to prove that the nanoparticle-mediated delivery of 2DG results in greater concentrations of 2DG in the tumor tissues than is realized by direct delivery of 2DG, …