2024年12月25日 · NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include Liddle Syndrome 1 and Charcot-Marie-Tooth Disease Type 1C. Among its related pathways are PIP3 activates AKT signaling and Class I MHC mediated antigen processing and presentation.

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene. [5][6] NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. [7] .

2019年12月2日 · Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration, and invasion of cancer...

A growing amount of evidence indicates that the neuronally expressed developmentally downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a variety of cellular processes via the ubiquitination-mediated degradation of multiple substrates.

2009年6月26日 · The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member ...

NEDD4 is an autophagic E3 ubiquitin ligase that ubiquitylates SQSTM1, facilitating SQSTM1-mediated inclusion body autophagy. NEDD4 is largely involved in epithelial-mesenchymal transition features and chemoresistance of nasopharyngeal carcinoma cancer cells.

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin Proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin Ligase catalytic domain.

2025年1月31日 · nedd4(表达发育下调的神经元前体细胞4)，也称为nedd4-1，是nedd4家族中的一种e3 ub(泛素)连接酶，含有hect结构域。 它通过不同靶点的泛素化在各种发病机制中发挥重要作用。

2025年1月23日 ，南京医科大学 / 哈尔滨医科大学季勇教授团队 在国际期刊《循环研究》（ Circulation Research ） 杂志上发表题为 《 NEDD4 介导的 GSNOR 降解加重心肌肥大和 心 功能障碍 》（ NEDD4-mediated GSNOR degradation aggravates cardiac hypertrophy and dysfunction ） 的研究论文。 该论文 首次发现 E 3 泛素酶神经元前 ...

它是泛素连接酶复合物的一部分。它在突触后胞质中活性。它在几个结构中表达，包括消化系统；眼睛；生殖泌尿系统；肢；和神经系统。该蛋白质与人类nedd4（nedd4 e3泛素蛋白连接酶）正同源。