
NEDD4 Gene - GeneCards | NEDD4 Protein | NEDD4 Antibody
2024年12月25日 · NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include Liddle Syndrome 1 and Charcot-Marie-Tooth Disease Type 1C. Among its related pathways are PIP3 activates AKT signaling and Class I MHC mediated antigen processing and presentation.
NEDD4 - Wikipedia
E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene. [5][6] NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. [7] .
The many substrates and functions of NEDD4-1 - Nature
2019年12月2日 · Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration, and invasion of cancer...
NEDD4 E3 ligase: Functions and mechanism in human cancer
A growing amount of evidence indicates that the neuronally expressed developmentally downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a variety of cellular processes via the ubiquitination-mediated degradation of multiple substrates.
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with ...
2009年6月26日 · The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member ...
NEDD4 NEDD4 E3 ubiquitin protein ligase [ (human)]
NEDD4 is an autophagic E3 ubiquitin ligase that ubiquitylates SQSTM1, facilitating SQSTM1-mediated inclusion body autophagy. NEDD4 is largely involved in epithelial-mesenchymal transition features and chemoresistance of nasopharyngeal carcinoma cancer cells.
NEDD4 E3 泛素蛋白连接酶(NEDD4)基因 | MCE
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin Proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin Ligase catalytic domain.
Circ Res:南京医科大学季勇等表明NEDD4介导的GSNOR降解加重 …
2025年1月31日 · nedd4(表达发育下调的神经元前体细胞4),也称为nedd4-1,是nedd4家族中的一种e3 ub(泛素)连接酶,含有hect结构域。 它通过不同靶点的泛素化在各种发病机制中发挥重要作用。
季勇教授团队首次揭示NEDD4介导的GSNOR泛素化在心肌肥厚中 …
2025年1月23日 ,南京医科大学 / 哈尔滨医科大学季勇教授团队 在国际期刊《循环研究》( Circulation Research ) 杂志上发表题为 《 NEDD4 介导的 GSNOR 降解加重心肌肥大和 心 功能障碍 》( NEDD4-mediated GSNOR degradation aggravates cardiac hypertrophy and dysfunction ) 的研究论文。 该论文 首次发现 E 3 泛素酶神经元前 ...
Nedd4小鼠基因|Nedd4基因功能|Nedd4小鼠模型-RDDC官网
它是泛素连接酶复合物的一部分。它在突触后胞质中活性。它在几个结构中表达,包括消化系统;眼睛;生殖泌尿系统;肢;和神经系统。该蛋白质与人类nedd4(nedd4 e3泛素蛋白连接酶)正同源。