NEDD8 Gene - GeneCards | NEDD8 Protein | NEDD8 Antibody
2024年12月25日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease. Among its …
Nature：揭示蛋白NEDD8诱导细胞中蛋白泛素化机制 - 华人研究 …
2020年3月28日 · 在所有E3连接酶中，它们的开启开关（on-switch）中的大约三分之一是一种类似于泛素的小蛋白，即NEDD8。 NEDD8控制对其他蛋白的关闭
泛素化太老套？国自然新热点拟素化（neddylation）修饰值得关注 …
拟素化修饰（Neddylation） 是近年来发现的新型蛋白质翻译后修饰，可以广泛地调节生物学过程，如细胞周期、信号传导和免疫识别等。 泛素样蛋白 NEDD8 通过类似泛素化的过程与目标 …
NEDD8 - Wikipedia
NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently …
蛋白质的肽修饰：泛素化、苏木化和NEDD化（二） - 知乎
NEDD8（neural precursor cell expressed, developmentally downregulated 8）最初在脑中发现，但后来证明它也是广泛表达的。 它由81个残基构成，与泛素相似性高达80%。 NEDD8前体 …
NEDD8活化酶(NAE)小分子抑制剂的研究进展 - 知乎
NEDD8 (Neural precursorcell-expressed developmentally downregulated 8) 是一种类泛素蛋白，与泛素具有约60% 的相似性和80%的同源性。 在 NEDD8活化酶 (NEDD8-Activating …
Protein neddylation and its role in health and diseases
2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein …
A Nedd8 conjugation pathway is essential for proteolytic …
Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell …
Structural and functional consequences of NEDD8 phosphorylation …
2021年10月12日 · NEDD8 is best known for its function as a stimulator of cullin-RING ligases (CRLs) via neddylation of cullin family proteins 4, 5. It also modifies many other proteins, …
NEDDylation promotes nuclear protein aggregation and …
2018年10月22日 · Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases …