Targeted mutation assessment of 81 genes in 1,021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, …

2022年11月15日 · NF1 mutations were found in about 5% of AML patients and may carry a worse prognosis. In this IRB-approved retrospective case-control study, we analyzed specific clinical …

2017年12月8日 · We detected a total of 59 NF1 mutations in 52 pts, for an overall frequency of 5.1% (5.2% in younger and 4.8% in older AML pts), which suggests NF1 belongs to the 20 …

2013年2月6日 · NF1 was initially identified in neurofibromatosis type 1 (NF1), an autosomal genetic disorder caused by heterozygous germline mutations or microdeletions affecting the …

2010年8月15日 · Primary AML blasts without functional NF1, unlike blasts with functional NF1, displayed sensitivity to rapamycin-induced apoptosis, thus identifying a dependence on …

2018年10月1日 · Eisfeld and colleagues recently described recurrent mutations in NF1 in patients with acute myeloid leukemia (AML), with a higher frequency than seen in previous studies. …

2008年4月15日 · Deletion of one allele of NF1 and further inactivation of the other NF1 allele in 3 patients through the acquisition of point mutations further confirms the role of NF1 as a tumor …