NF1 regulation of RAS/ERK signaling is required for appropriate …
The NF1 tumor suppressor gene encodes for neurofibromin, a RAS GTPase-activating protein (GAP) that promotes the conversion of an active RAS-GTP-bound form to an inactive RAS …
Neurofibromin Regulation of ERK Signaling Modulates GABA …
2008年10月31日 · We show that the learning deficits of Nf1+/− mice are due to increases in ERK activation that lead to higher levels of synapsin I phosphorylation, greater GABA release, and …
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I - Nature
2020年11月11日 · Here, we have sought targets offering a more narrow inhibition of ERK activation downstream of NF1 loss in the skeleton, finding that MEKK2 is a novel component …
ERK inhibition rescues defects in fate specification of Nf1 …
2012年8月17日 · Nf1-deficient brains exhibit enlarged corpus callosum, a structural defect linked to severe learning deficits in NF1 patients. Strikingly, these NF1-associated developmental …
NF1 regulation of RAS/ERK signaling is required for ... - PubMed
2014年11月1日 · The NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regulates the RAS signaling pathway. Here, using mouse models to direct …
Cell fate decisions are specified by the dynamic ERK interactome
2009年11月22日 · These results confirm a key role for Ras in shaping ERK response kinetics and suggest that NF1 is a crucial Ras regulator, in PC12 cells. Importantly, NF1 downregulation …
<br>同时抑制 SOS1 和 MEK 抑制 NF1 缺失黑色素瘤的 ... - X-MOL
神经纤维瘤 （NF1） 是 RAS 信号传导的负调节因子，在癌症中经常发生突变。 NF1 突变黑色素瘤是一种高度恶性的肿瘤，缺乏靶向治疗。 在这里，我们对患者来源的模型和同基因细胞系 …
NOTCH, ERK, and SHH signaling respectively control the fate
NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons. ... Y. Wang et al., ERK inhibition rescues defects in fate …
1型神经纤维瘤病MEK抑制剂治疗：临床证据和共识 - 搜狐
2022年12月15日 · 最近的研究表明，抑制ras下游丝裂原活化蛋白激酶（mek）活性可使nf1相关丛状神经纤维瘤（pn）缩小，司美替尼因此获批用于治疗有症状、不可手术的nf1相关pn儿童患 …
BRAF Mutants Evade ERK-Dependent Feedback by Different
2015年9月14日 · Oncogenic mutations of NRAS, KRAS, BRAF, MEK1, and NF1 drive the ERK-dependent growth of many human cancers. These mutations activate both downstream …