2015年11月30日 · Here we identify the transcription factor NFATc4 as a functional link connecting inflammation-induced EGFR signaling to acinar metaplasia and show that induction of Sox9 in …

Our findings identify an EGFR-NFATc1-Sox9 signaling cascade as a critical mediator of inflammation-induced PDAC initiation and suggest that disruption of this pathway may offer a …

2014年5月13日 · Mechanistically, Ca (2+) influx via Cav3.2 activates the calcineurin/nuclear factor of the activated T-cell (NFAT) signaling pathway, and a previously unidentified NFAT binding …

We identified an NFAT binding motif (TTTCC) in the mouse Sox9 promoter that was required for Ca v 3.2-dependent Sox9 regulation on Luc reporter assay. In addition, NFAT directly bound …

2021年1月1日 · Sox9 in situ hybridization after 24 h of WNT5A or CaN inhibitor or NFAT inhibitor bead implantation followed by 1 h or 4 h of TGFβ treatment. Experimental design showing …

Mechanistically, Wnt5a acts to increase chondrocyte differentiation at an early stage through calmodulin kinase /NFAT-dependent induction of Sox9. Conversely, Wnt5a represses …

2015年5月1日 · Induction of EGFR signaling and its effects on the expression of Nuclear factor of activated T cells c1 (NFATc1) or SOX9 were investigated by quantitative reverse-transcription …

Induction of EGFR signaling and its effects on the expression of Nuclear factor of activated T cells c1 (NFATc1) or SOX9 were investigated by quantitative reverse-transcription polymerase …

group-Box gene 9 (Sox9), one of the earliest markers of committed chondrogenic cells, is reduced in Ca v3.2 −/ tracheas. Mechanistically, Ca2+ influx via Ca v3.2 activates the …

In this study, we first demonstrated that RCAN1.4 is positively associated with disc degeneration and that hypoxia-induced downregulation of RCAN1.4 activated the calcineurin/NFAT …