2024年12月25日 · NFAT5 (Nuclear Factor Of Activated T Cells 5) is a Protein Coding gene. Diseases associated with NFAT5 include Granulomatous Disease, Chronic, Autosomal Recessive, 3 and Visceral Myopathy 1. Among its related pathways are Activation of cAMP-Dependent PKA and TCR Signaling (Qiagen).

Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.

2025年2月8日 · Results suggest that the NFAT5 gene, which is upregulated a few hours after cocaine exposure, may be involved in the genetic predisposition to cocaine dependence. NFAT5 pathway activation might have a relevant role in inflammatory breast cancer pathogenesis

The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive enhancer-binding protein, was originally identified as a key transcription factor involved in maintaining cellular homeostasis against hypertonic and hyperosmotic ...

The NFAT5 gene is widely transcribed and encodes a protein of 1,455 aa. In contrast to the conventional NFAT proteins, NFAT1–4, which show high and moderate sequence identity in their DNA-binding and N-terminal regulatory domains, respectively, NFAT5 exhibits a clear relation to NFAT proteins only in its Rel-like DNA-binding domain.

2019年2月18日 · Transcription factor NFAT5 induces the expression of a variety of osmoprotective genes, including ion transporters, aldose reductase, and heat shock protein 70, for intracellular distribution of compatible osmolytes and urea (4).

2024年8月27日 · HIV-1 PR is identified to have a physical interaction with nuclear factor of activated T-cells 5, tonicity-responsive (NFAT5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses

2025年2月8日 · Identify NFAT5 as a novel regulator of vascular smooth muscle cell phenotypic modulation. Hypertonic stress activates mTERT transcription via the activation and recruitment of NFAT5 to the mTERT promoter. NFAT5-dependent CD24 induction contributes to T-cell expansion under hypertonic stress in a mouse model.

This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements.

2023年9月14日 · Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic infections and tumors but...