Following the discovery of the neurotrophin-binding Trk receptors with kinase activity, the lack of obvious catalytic domains in p75 ICD relegated p75 to be considered an adaptor protein, incapable of activating signaling cascades and instead partnering with TrkA to enhance NGF trophic signaling (38, 39).

Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of cell-surface proteins, the Trk family of receptor tyrosine kinases, and the p75, or low-affinity neurotrophin receptor.

2004年5月7日 · Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 Å crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75.

2000年8月1日 · Nerve growth factor (NGF) binds to two neurotrophin receptors: p75 (NTR) and p140 (Trk) (TrkA). Both receptors dimerize in response to NGF binding. TrkA homodimers and heteromers of TrkA and p75 (NTR) promote cell survival whereas homodimers of p75 (NTR) mediate apoptosis upon binding of NGF.

2007年1月4日 · Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a “high-affinity” NGF binding site through formation of a ternary TrkA/NGF/p75 complex.

2015年9月15日 · In the presence of TrkA receptor, p75 NTR facilitates high affinity binding of NGF and activation of cell survival pathways, while, in the absence of TrkA receptor, p75 NTR induces cell death...

Nerve growth factor (NGF) signaling plays a key role in neuronal development, function, survival, and growth. 1 NGF signals by binding two types of membrane receptors: tropomyosin-related kinase A (TrkA) and p75 neurotrophin receptor (p75), a member of the tumor necrosis factor superfamily. 1,2 Both receptors can function independently by ...

2010年1月1日 · Therapeutic antagonists of NGF signaling for the control of neuroinflammatory pain have been developed by targeting the growth factor with a high-affinity monoclonal antibody that binds the neurotrophin fold “waist” in a manner that would block either p75 or Trk binding.

2004年5月7日 · A particularly intriguing prediction of this model is that there is room for binding of Trk receptors to the NGF-p75 complex (see the figure). This mechanism had been proposed on the basis of reconstitution binding experiments showing that p75 and TrkA are responsible for high-affinity NGF binding sites ( 12 ).

2020年9月11日 · Neurotrophins bind to two distinct types of receptors including p75 neurotrophin receptor (p75NTR) with a lower affinity, as well as to the tropomyosin receptor kinases (Trk) receptors, which...