HLA typing by next-generation sequencing (NGS) generates unambiguous, phase-resolved HLA typing results using a single assay, system, and analysis program. The HLA region is the most …

随着二代测序技术的不断发展，基于 ngs 的hla分型中应运而生。它具有通量高、实验周期短、高分辨率和成本低等特点，本篇主要介绍利用生物信息的手段对ngs的数据进行hla分型。

2020年6月14日 · HLA (human leukocyte antigen ，人类白细胞抗原)是人类的主要组织相容性复合体（MHC）的表达产物，该系统是所知人体最复杂的多态系统。 HLA是具有高度多态性的同 …

2015年8月27日 · Research on the human leukocyte antigen (HLA), an extensively studied molecule involved in immunity, has benefitted from NGS technologies. The HLA region, a 3.6 …

Here, we introduce the first highly automated open-kit/open-source HLA-typing method for NGS. The method employs in-solution targeted capturing of the classical class I (HLA-A, HLA-B, …

This brief review will summarize the utility of next-generation sequencing (NGS) for HLA genotyping, highlighting the advantages of this approach over other molecular methods for …

2015年6月23日 · High-quality NGS-based methods are in proprietary use and not publicly available. Here, we introduce the first highly automated open-kit/open-source HLA-typing …

2025年1月15日 · Next-generation sequencing (NGS) is revolutionizing HLA gene analysis with its ability to identify allelic variants (haplotypes) and rare polymorphisms. Unlike traditional …

2023年2月22日 · Next-generation sequencing (NGS) has revolutionized clinical genotyping, providing high-resolution HLA genotyping with a low ambiguity rate. This study aimed to …

The advent of next generation sequencing (NGS) has altered the face of genotyping the human leukocyte antigen (HLA) system in clinical, stem cell donor registry, and research contexts. …