Decarboxylative Cross-Electrophile Coupling of
2016年3月30日 · We show here a complementary approach: coupling of NHP esters with aryl iodides to form alkylated arenes without the need for a cocatalyst or light (Scheme 1). Scheme 1. Conversion of Alkanoic Acids to Radicals.
Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide ...
2016年4月20日 · A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with aryl iodides is presented. In contrast to previous studies that form alkyl radicals from carboxylic acid derivatives, no photocatalyst, light, or arylmetal reagent is needed, only nickel and a reduci …
Gregory Fu报道Curtius重排的改良反应：NHP酯的脱羧偶联- X …
2017年9月24日 · 最近，来自美国加州理工学院的Gregory C. Fu教授（点击查看介绍）课题组报道了以NHP酯作为底物，在可见光诱导与Cu催化剂的作用下脱羧形成烷基自由基中间体，进而与邻苯二甲酰亚胺负离子偶联形成脂肪胺产物。
Recent progress in reactivity study and synthetic application of N ...
2020年9月30日 · In summary, we have outlined recent progress in NHP chemistry, with special attention to reactivity studies and synthetic applications. The recently disclosed NHP hydricity, as a surrogate for metal-based hydricity, has opened up a new avenue to main-group hydrides, and complements conventional P–H protonic reactivity.
Mechanistic Investigation of Ni-Catalyzed Reductive Cross …
2023年6月26日 · In this study, we sought to (1) determine the kinetic driving forces and resting state for the homogeneous reaction of alkenyl bromide 1a with NHP ester 2b; (2) investigate the redox properties of the L1 ·Ni II X 2 precatalysts and determine whether L1 ·Ni 0 is accessible using common reductants; (3) interrogate the mechanism of electrophile act...
Nickel-catalyzed electrochemical reductive decarboxylative coupling of
2019年11月12日 · Herein the first example of electrochemically enabled, NiCl2-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxyl
NHPs 的合成应用：从氢化物途径到自由基机制,Chemical …
2022年10月7日 · N-杂环膦 (NHPs)独特的杂环骨架赋予了它们优异的氢化反应性，这使得NHPs在过去几十年中被广泛应用于不饱和底物的催化氢化反应中。 最近，NHP 在自由基还原中的应用，尤其是催化方式，已成为一个有前途的前沿领域。
可见光诱导的香豆素与NHP酯选择性脱羧烷基化反应
2020年2月4日 · 浙江工业大学药学院（协同创新中心）金灿、颜志阳、孙彬等设计了一种可见光诱导NHP酯（N-烷酰氧基邻苯二甲酰亚胺）与香豆素脱羧偶联反应，实现3位长链伯烷基取代的香豆素衍生物的合成。
中南大学阳华/向皞月课题组Org. Lett.: 光诱导钯催化1,3-二烯与NHP …
2024年10月30日 · 研究发现，从易获得的直链、支链脂肪族一级、二级羧酸衍生出的各种NHP酯均能适用于该反应，以中等至良好的产率、对映选择性得到相应的手性烯丙基胺产物。
Post list for NHP酯 - 化学空间 Chem-Station
本文作者:杉杉导读近日，Wisconsin大学的D. J. Weix课题组在Org. Lett.中发表论文，报道一种全新的采用镍催化剂促进的非活化烷基溴与原位形成的NHP酯 (N-hydroxyphthalimide esters)… Pick UP!