2022年5月30日 · This article provides evidence that MULT1, a shed ligand for the receptor NKG2D, in mice, enhances NK cell activation by blocking interactions of NK cells with cell …

Major histocompatibility complex class I specific inhibitory receptors expressed by NK cells have two distinct roles: while allowing self tolerance, they are also needed for the acquisition of NK …

2016年6月6日 · Natural killer (NK) cell education, a process for achieving functional maturation and self-tolerance, has been previously defined by the interaction between self-major...

2005年4月20日 · Carcinoembryonic-antigen-related cell-adhesion molecule 1 (CEACAM1) ensures NK-cell tolerance in MHC-class-I-deficient humans. Several other NK-cell inhibitory...

Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been …

2006年3月4日 · Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate normal cells from cells in distress. In humans, this “missing self” recognition is …

1998年3月20日 · As predicted, NK cells have been shown to express receptors for MHC class I that upon ligation inhibit NK cell-mediated cytotoxicity and cytokine secretion (reviewed by …

2012年4月1日 · A group of inhibitory receptors interacts specifically with major histocompatibility complex (MHC) class I molecules. These receptors prevent NK cell-mediated attack against …

1998年7月15日 · P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of …

Natural killer (NK) cells, like B and T lymphocytes, are potent effector cells that are crucial for immunity to tumors and infections. These effector responses must be controlled to avoid …