NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. [5][6] The NLRC4 protein is highly conserved across mammalian species. It bears homology to the C. elegans Ced4 protein.

2024年12月25日 · NLRC4 (NLR Family CARD Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRC4 include Familial Cold Autoinflammatory Syndrome 4 and Autoinflammation With Infantile Enterocolitis. Among its related pathways are Gene expression (Transcription) and TP53 Regulates Transcription of Cell Death Genes.

The NLRC4 inflammasomopathies are caused by gain-of-function mutations in the gene encoding the innate immune protein NLRC4. Mutant NLRC4 promotes spontaneous formation of the NLRC4 inflammasome, production of IL1 family cytokines …

The current understanding of the NLRC4 inflammasome is perhaps the most comprehensive illustration of the inflammasome paradigm: trigger (e.g. cytosolic flagellin), sensor (NAIP), nucleator (NLRC4), adaptor (ASC), and effector (CASP1). Detailed work has also identified observations that challenge this paradigm.

2021年11月30日 · We explored whether NLRC4 knockdown alleviated inflammatory injury following intracerebral hemorrhage (ICH). Furthermore, we investigated whether NLRC4 inflammasome activation can be adjusted...

In this review we give an overview of the NAIP/NLRC4 activation mechanism as well as the described roles of this inflammasome, with a focus on in vivo infection and pathology. After ligand recognition by NAIP sensor proteins the NAIP/NLRC4 inflammasome forms through oligomerization with the NLRC4 ad …

2024年1月4日 · The NLR family caspase activation and recruitment domain-containing 4 (NLRC4) inflammasome is a critical cytosolic innate immune machine formed upon the direct sensing of bacterial infection and...

NLRC4是NOD样受体家族中的一员，主要感受细菌的鞭毛蛋白和III型分泌系统等成分，从而引发对相关病原菌入侵的免疫应答。 NLRC4在正常情况下通过自抑制作用处于静息状态；当病原菌成分进入细胞内时，会被另一类NOD样受体家族蛋白--NAIP亚家族蛋白所识别并激活，从而进一步活化NLRC4；活化的NLRC4会发生自身多聚化并招募Caspase-1，形成炎症小体，产生一系列的免疫应 …

2011年9月14日 · The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod component3,4,5.

In this review article, we provide an updated overview of NLRC4 inflammasomes, describing their composition, activation mechanisms and roles in both microbial infections and other disease conditions. Keywords: NLRC4, inflammasome, autoimmune disease, cancer, PANoptosis.