NLRP1 - Wikipedia
NLRP1 encodes NACHT, LRR, FIIND, CARD domain and PYD domains-containing protein 1 in humans. [5] [6] [7] NLRP1 was the first protein shown to form an inflammasome. [8] NLRP1 is …
Science 背靠背| 破解NLRP1炎症小体的活化之谜 - 知乎
NLRP1是NLR家族中比较异类的存在，其含有未知功能的FIIND（function-to-find domain）结构域，且其可激活Caspase位于蛋白C端的CARD（caspase activation and recruitment domain） …
Science | 双链RNA的感受器NLRP1——人源NLRP1识别RNA病毒感 …
慕尼黑工业大学的Veit Hornung课题组长期关注固有免疫中病原识别受体的功能，日前在Science发表题为 Human NLRP1 is a sensor for double-stranded RNA 的研究，发现皮肤组织内 …
NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 …
2023年12月16日 · This review focuses on recent studies identifying new human-specific NLRP1 mechanisms of activation of, gain-of-function human variants and disease, its role in …
炎性小体 - 百度百科
已发现的炎性小体主要有5种，即 nlrp1炎性小体、nlrp3炎性小体、nlrc4炎性 小体 、 ipaf炎性小体和aim2炎性小体。 已知发现的炎性小体一般均含有凋亡相关微粒蛋白（ apoptosis …
NLRP1 Gene - GeneCards | NLRP1 Protein | NLRP1 Antibody
2024年12月25日 · NLRP1 (NLR Family Pyrin Domain Containing 1) is a Protein Coding gene. Diseases associated with NLRP1 include Respiratory Papillomatosis, Juvenile Recurrent, …
Structural basis for thioredoxin-mediated suppression of NLRP1
2023年9月13日 · Here we identify ubiquitously expressed endogenous thioredoxin (TRX) as a binder of NLRP1 and a suppressor of the NLRP1 inflammasome. The cryo-electron …
梁启明团队《Nat Immunol》发文报道NLRP1炎症小体的非经典激 …
2022年7月6日 · NLRP1是NOD样受体家族中第一个被发现可以与ASC和caspase1形成复合体的蛋白，NLRP1 FIIND结构域可自发部分水解，产生NLRP1NT和NLRP1CT两条多肽链。 其 …
The NLRP1 inflammasome: new mechanistic insights and …
We discuss a newly proposed 'functional degradation' mechanism that explains activation and assembly of NLRP1 into an oligomeric complex called an inflammasome. We also discuss …
Functional degradation: A mechanism of NLRP1 inflammasome
2019年3月14日 · Proteases such as anthrax lethal factor can activate an inflammasome known as NLRP1B, but the mechanism for this activation has been unclear. Chui et al. used genome …